Simona Marzano
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Explore the profile of Simona Marzano including associated specialties, affiliations and a list of published articles.
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14
Citations
43
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Recent Articles
1.
Marzano S, Pinto G, Di Porzio A, Amato J, Randazzo A, Amoresano A, et al.
Commun Chem
. 2025 Mar;
8(1):64.
PMID: 40025218
G-quadruplexes (G4s) are noncanonical DNA or RNA secondary structures involved in numerous biological processes. Their recognition by G4-related proteins (G4RPs) is essential for modulating biological pathways, particularly those associated with...
2.
Moraca F, Arciuolo V, Marzano S, Napolitano F, Castellano G, DAria F, et al.
Eur J Med Chem
. 2025 Jan;
285:117245.
PMID: 39793440
Breast cancer, a leading cause of cancer-related mortality in women, is characterized by genomic instability and aberrant gene expression, often influenced by noncanonical nucleic acid structures such as G-quadruplexes (G4s)....
3.
Salerno S, Barresi E, Roggia M, Natale B, Marzano S, Hyeraci M, et al.
ACS Med Chem Lett
. 2024 Nov;
15(11):1875-1883.
PMID: 39563818
Here, we explored the benzothiopyranoindole scaffold to develop antiproliferative agents with a polypharmacological profile targeting both G-quadruplex (G4)-structures and Topoisomerase (Topo) I enzyme. In a preliminary optimization phase, compound was...
4.
Sensitization of melanoma cells to standard chemotherapy: G-quadruplex binders as synergistic agents
Persico C, Iaccarino N, Romano F, Giustiniano M, Russo C, Laneri S, et al.
NAR Cancer
. 2024 Oct;
6(4):zcae042.
PMID: 39478935
The use of chemotherapeutics has achieved considerable success in cancer therapy; however, their toxicity can severely impact patients' health. In this study, aiming to reduce the doses and potential side...
5.
Nocentini A, Di Porzio A, Bonardi A, Bazzicalupi C, Petreni A, Biver T, et al.
J Enzyme Inhib Med Chem
. 2024 Jun;
39(1):2366236.
PMID: 38905127
A novel class of compounds designed to hit two anti-tumour targets, G-quadruplex structures and human carbonic anhydrases (hCAs) IX and XII is proposed. The induction/stabilisation of G-quadruplex structures by small...
6.
Merlino F, Marzano S, Zizza P, DAria F, Grasso N, Carachino A, et al.
Nucleic Acids Res
. 2024 Jun;
52(12):6748-6762.
PMID: 38828773
Noncanonical nucleic acid structures, particularly G-quadruplexes, have garnered significant attention as potential therapeutic targets in cancer treatment. Here, the recognition of G-quadruplex DNA by peptides derived from the Rap1 protein...
7.
Grasso N, Graziano R, Marzano S, DAria F, Merlino F, Grieco P, et al.
Int J Biol Macromol
. 2023 Sep;
253(Pt 3):126749.
PMID: 37689293
G-quadruplexes are non-canonical DNA secondary structures formed within guanine-rich strands that play important roles in various biological processes, including gene regulation, telomere maintenance and DNA replication. The biological functions and...
8.
Saviano A, Manosour A, Raucci F, Merlino F, Marigliano N, Schettino A, et al.
Ann Rheum Dis
. 2023 Aug;
82(11):1415-1428.
PMID: 37580108
Objectives: Interleukin (IL) 17s cytokines are key drivers of inflammation that are functionally dysregulated in several human immune-mediated inflammatory diseases (IMIDs), such as rheumatoid arthritis (RA), psoriasis and inflammatory bowel...
9.
Donati G, DAmore V, Russomanno P, Cerofolini L, Amato J, Marzano S, et al.
Comput Struct Biotechnol J
. 2023 Jun;
21:3355-3368.
PMID: 37384351
Today it is widely recognized that the PD-1/PD-L1 axis plays a fundamental role in escaping the immune system in cancers, so that anti-PD-1/PD-L1 antibodies have been evaluated for their antitumor...
10.
Miglione A, Raucci A, Amato J, Marzano S, Pagano B, Raia T, et al.
Anal Chem
. 2022 Nov;
94(45):15558-15563.
PMID: 36318963
The development of electrochemical strips, as extremely powerful diagnostic tools, has received much attention in the field of sensor analysis and, in particular, the detection of nucleic acids in complex...