Simon Schafer
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Explore the profile of Simon Schafer including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
494
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Recent Articles
21.
Werner A, Schafer S, Gleussner N, Nimmerjahn F, Winkler T
STAR Protoc
. 2022 Apr;
3(2):101277.
PMID: 35434659
High-throughput antibody repertoire analysis via next-generation sequencing is a key method in understanding humoral immunity. Errors introduced during library preparation and sequencing can be corrected with molecular amplification fingerprinting using...
22.
Rentsch C, Thalmann G, Lucca I, Kwiatkowski M, Wirth G, Strebel R, et al.
Eur Urol Oncol
. 2022 Jan;
5(2):195-202.
PMID: 35012889
Background: VPM1002BC is a genetically modified Mycobacterium bovis bacillus Calmette-Guérin (BCG) strain with potentially improved immunogenicity and attenuation. Objective: To report on the efficacy, safety, tolerability and quality of life...
23.
Burnett D, Jackson K, Langley D, Aggrawal A, Stella A, Johansen M, et al.
Immunity
. 2021 Nov;
54(12):2908-2921.e6.
PMID: 34788600
Viral mutations are an emerging concern in reducing SARS-CoV-2 vaccination efficacy. Second-generation vaccines will need to elicit neutralizing antibodies against sites that are evolutionarily conserved across the sarbecovirus subgenus. Here,...
24.
Werner A, Schafer S, Zaytseva O, Albert H, Lux A, Kristic J, et al.
iScience
. 2021 Sep;
24(9):103076.
PMID: 34585117
Systemic lupus erythematosus (SLE) is characterized by a loss of self-tolerance, systemic inflammation, and multi-organ damage. While a variety of therapeutic interventions are available, it has become clear that an...
25.
Kammerer T, Faihs V, Hulde N, Stangl M, Brettner F, Rehm M, et al.
Int J Mol Sci
. 2020 Feb;
21(3).
PMID: 32033172
Induction of hypoxia-inducible-factor-1α (HIF-1α) pathway and HIF-target genes allow adaptation to hypoxia and are associated with reduced incidence of acute mountain sickness (AMS). Little is known about HIF-pathways in conjunction...
26.
Herdy J, Schafer S, Kim Y, Ansari Z, Zangwill D, Ku M, et al.
Elife
. 2019 May;
8.
PMID: 31099332
Direct conversion of human somatic fibroblasts into induced neurons (iNs) allows for the generation of functional neurons while bypassing any stem cell intermediary stages. Although iN technology has an enormous...
27.
Rump K, Unterberg M, Bergmann L, Bankfalvi A, Menon A, Schafer S, et al.
J Transl Med
. 2016 Nov;
14(1):321.
PMID: 27871297
Background: The C-allele of the aquaporin (AQP5) -1364A/C polymorphism is associated with decreased AQP5 expression but increased 30-day survival in patients with severe sepsis. AQP5 expression might affect survival via...
28.
Kruger A, Oldenburg M, Chebrolu C, Beisser D, Kolter J, Sigmund A, et al.
EMBO Rep
. 2015 Nov;
16(12):1656-63.
PMID: 26545385
Toll-like receptor (TLR) 13 and TLR2 are the major sensors of Gram-positive bacteria in mice. TLR13 recognizes Sa19, a specific 23S ribosomal (r) RNA-derived fragment and bacterial modification of Sa19...
29.
Wanka H, Staar D, Lutze P, Peters B, Hildebrandt J, Beck T, et al.
J Mol Med (Berl)
. 2015 Aug;
94(1):61-9.
PMID: 26256830
Unlabelled: In the heart, secretory renin promotes hypertrophy, apoptosis, necrosis, fibrosis, and cardiac failure through angiotensin generation from angiotensinogen. Thus, inhibitors of the renin-angiotensin system are among the most potent...
30.
Paasche A, Zipper A, Schafer S, Ziebuhr J, Schirmeister T, Engels B
Biochemistry
. 2014 Sep;
53(37):5930-46.
PMID: 25196915
The coronavirus main protease (M(pro)) represents an attractive drug target for antiviral therapy of coronavirus (CoV) infections, including severe acute respiratory syndrome (SARS). The SARS-CoV M(pro) and related CoV proteases...