Simon L Rossler
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Explore the profile of Simon L Rossler including associated specialties, affiliations and a list of published articles.
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12
Citations
170
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Recent Articles
1.
Grob N, Remarcik C, Rossler S, Wong J, Wang J, Tao J, et al.
ACS Chem Biol
. 2023 Dec;
19(1):101-109.
PMID: 38069818
Protein-protein interactions (PPIs) are intriguing targets in drug discovery and development. Peptides are well suited to target PPIs, which typically present with large surface areas lacking distinct features and deep...
2.
Truex N, Rondon A, Rossler S, Hanna C, Cho Y, Wang B, et al.
ACS Cent Sci
. 2023 Oct;
9(9):1835-1845.
PMID: 37780364
Molecular vaccines comprising antigen peptides and inflammatory cues make up a class of therapeutics that promote immunity against cancer and pathogenic diseases but often exhibit limited efficacy. Here, we engineered...
3.
Rossler S, Grob N, Buchwald S, Pentelute B
Science
. 2023 Mar;
379(6635):939-945.
PMID: 36862767
Encoding small-molecule information in DNA has been leveraged to accelerate the discovery of ligands for therapeutic targets such as proteins. However, oligonucleotide-based encoding is hampered by inherent limitations of information...
4.
Rossler S, Jelier B, Magnier E, Dagousset G, Carreira E, Togni A
Angew Chem Int Ed Engl
. 2019 Oct;
59(24):9264-9280.
PMID: 31600423
In this Review, we highlight recent advances in the understanding and design of N-functionalized pyridinium scaffolds as redox-active, single-electron, functional group transfer reagents. We provide a selection of representative methods...
5.
Rossler S, Petrone D, Carreira E
Acc Chem Res
. 2019 Jun;
52(9):2657-2672.
PMID: 31243973
The catalytic, asymmetric synthesis of complex molecules has been a core focus of our research program for some time because developments in the area can have an immediate impact on...
6.
Sempere Y, Alfke J, Rossler S, Carreira E
Angew Chem Int Ed Engl
. 2019 May;
58(28):9537-9541.
PMID: 31069899
Morpholine ketene aminal is employed in iridium-catalyzed asymmetric allylic alkylation reactions as a surrogate for amide enolates to prepare γ,δ-unsaturated β-substituted morpholine amides. Kinetic resolution or, alternatively, stereospecific substitution affords...
7.
Rossler S, Jelier B, Tripet P, Shemet A, Jeschke G, Togni A, et al.
Angew Chem Int Ed Engl
. 2018 Nov;
58(2):526-531.
PMID: 30398683
Electron-transfer photocatalysis provides access to the elusive and unprecedented N-pyridyl radical cation from selected N-substituted pyridinium reagents. The resulting C(sp )-H functionalization of (hetero)arenes furnishes versatile intermediates for the development...
8.
Petrone D, Isomura M, Franzoni I, Rossler S, Carreira E
J Am Chem Soc
. 2018 Mar;
140(13):4697-4704.
PMID: 29488753
An enantioconvergent C(sp)-C(sp) coupling between racemic allenylic electrophiles and alkylzinc reagents has been developed. An Ir/(phosphoramidite,olefin) catalyst provides access to highly enantioenriched allenylic substitution products (93-99% ee) with complete regiocontrol...
9.
Rossler S, Schreib B, Ginterseder M, Hamilton J, Carreira E
Org Lett
. 2017 Oct;
19(20):5533-5536.
PMID: 28968123
Herein, the first total synthesis and stereochemical assignment of (+)-broussonetine H are reported. The ambiguous stereocenters within different fragments were independently installed through asymmetric methods, namely a diastereo- and enantioselective,...
10.
Hamilton J, Rossler S, Carreira E
J Am Chem Soc
. 2017 Jun;
139(24):8082-8085.
PMID: 28598614
Iridium-(P,olefin) complex-catalyzed enantio- and diastereoselective formation of substituted spiroketals from racemic, allylic carbonates is reported, which enables the installation of multiple stereogenic centers in a single operation. The protocol was...