Simon J F Macdonald
Overview
Explore the profile of Simon J F Macdonald including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
75
Citations
854
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Robinson H, Stillibrand J, Simelis K, Macdonald S, Nortcliffe A
Org Biomol Chem
. 2025 Jan;
18(34):6696-6701.
PMID: 39825505
Iridium-catalysed catalytic, regioselective C-H borylation of β-aryl-aminopropionic acid derivatives gives access to 3,5-functionalised protected β-aryl-aminopropionic acid boronates. The synthetic versatility of these new boronates is demonstrated through sequential one-pot functionalisation...
2.
Hryczanek H, Barrett J, Barrett T, Burley G, Cookson R, Hatley R, et al.
J Med Chem
. 2024 Oct;
67(21):19689-19715.
PMID: 39417301
The αβ integrin has been identified as a target for the treatment of fibrotic diseases, based on the role it has in activating TGF-β, a protein implicated in the pathogenesis...
3.
Procopiou P, Barrett J, Crawford M, Hatley R, Hancock A, Pritchard J, et al.
J Med Chem
. 2024 Sep;
67(19):17497-17519.
PMID: 39269712
A series of 3-aryl(()-3-fluoropyrrolidin-1-yl)butanoic acids were developed as potent orally bioavailable αβ integrin inhibitors. Starting from a zwitterionic peptidomimetic series optimized for inhaled administration, the balancing of potency and passive...
4.
Clark J, Salgado-Polo F, Macdonald S, Barrett T, Perrakis A, Jamieson C
J Med Chem
. 2022 Apr;
65(8):6338-6351.
PMID: 35440138
Autotaxin (ATX) facilitates the hydrolysis of lysophosphatidylcholine to lysophosphatidic acid (LPA), a bioactive phospholipid, which facilitates a diverse range of cellular effects in multiple tissue types. Abnormal LPA expression can...
5.
Hatley R, McLachlan S, Baster K, Gelder L, Macdonald S
J Med Chem
. 2021 Dec;
65(1):37-57.
PMID: 34931848
A bibliometric study of authors across medicinal chemistry journals over 20 years reveals important trends. Most United States (US) based authors are assigned as racially/ethnically Asian or White; few are...
6.
Wilkinson A, John A, Barrett J, Gower E, Morrison V, Man Y, et al.
Eur J Pharmacol
. 2021 Nov;
913:174618.
PMID: 34762934
Fibrosis is the formation of scar tissue due to injury or long-term inflammation and is a leading cause of morbidity and mortality. Activation of the pro-fibrotic cytokine transforming growth factor-β...
7.
Macdonald S, Clarke G, Dowle M, Harrison L, Hodgson S, Inglis G, et al.
J Org Chem
. 2021 Jul;
64(14):5166-5175.
PMID: 34237863
A flexible, practical, and stereoselective synthesis of enantiomerically pure -5-oxohexahydropyrrolo[3,2-]pyrroles (pyrrolidine--lactams) is described. The key reaction involves addition of -ketene acetal to the acyliminium ion derived from . This reaction...
8.
Hatley R, Procopiou P, McLachlan S, Westendorf L, Meanwell N, Ewing W, et al.
J Med Chem
. 2020 Oct;
63(23):14336-14356.
PMID: 33103431
Writing scientific articles is immensely rewarding but challenging. This Perspective provides the medicinal chemist with background and advice on the art and process of writing manuscripts and complements the instructions...
9.
John A, Graves R, Pun K, Vitulli G, Forty E, Mercer P, et al.
Nat Commun
. 2020 Sep;
11(1):4659.
PMID: 32938936
The αvβ6 integrin plays a key role in the activation of transforming growth factor-β (TGFβ), a pro-fibrotic mediator that is pivotal to the development of idiopathic pulmonary fibrosis (IPF). We...
10.
Guest E, Oatley S, Macdonald S, Hirst J
J Chem Inf Model
. 2020 May;
60(11):5487-5498.
PMID: 32421320
The urgent need for new treatments for the chronic lung disease idiopathic pulmonary fibrosis (IPF) motivates research into antagonists of the RGD binding integrin αvβ6, a protein linked to the...