Simon I R Lane
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Explore the profile of Simon I R Lane including associated specialties, affiliations and a list of published articles.
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26
Citations
616
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Recent Articles
11.
Lane S, Crouch S, Jones K
Methods Mol Biol
. 2017 Mar;
1471:245-254.
PMID: 28349400
Accurate chromosome segregation is necessary so that genetic material is equally shared among daughter cells. However, maturing mammalian oocytes are particularly prone to chromosome segregation errors, making them a valuable...
12.
Hamdan M, Jones K, Cheong Y, Lane S
Sci Rep
. 2016 Nov;
6:36994.
PMID: 27841311
Mouse oocytes respond to DNA damage by arresting in meiosis I through activity of the Spindle Assembly Checkpoint (SAC) and DNA Damage Response (DDR) pathways. It is currently not known...
13.
Zarate-Garcia L, Lane S, Merriman J, Jones K
Sci Rep
. 2016 Jun;
6:27991.
PMID: 27301892
Whether the adult mammalian ovary contains oogonial stem cells (OSCs) is controversial. They have been isolated by a live-cell sorting method using the germ cell marker DDX4, which has previously...
14.
Collins J, Lane S, Merriman J, Jones K
Nat Commun
. 2015 Nov;
6:8553.
PMID: 26522232
Extensive damage to maternal DNA during meiosis causes infertility, birth defects and abortions. However, it is unknown if fully grown oocytes have a mechanism to prevent the creation of DNA-damaged...
15.
Yun Y, Holt J, Lane S, McLaughlin E, Merriman J, Jones K
Cell Cycle
. 2014 Apr;
13(12):1938-47.
PMID: 24758999
Currently, maternal aging in women, based on mouse models, is thought to raise oocyte aneuploidy rates, because chromosome cohesion deteriorates during prophase arrest, and Sgo2, a protector of centromeric cohesion,...
16.
Lane S, Jones K
Nat Commun
. 2014 Mar;
5:3444.
PMID: 24637522
The spindle assembly checkpoint (SAC) prevents aneuploidy by coupling anaphase onset, through anaphase-promoting complex (APC) activation, with chromosome attachment to spindle microtubules. Here, we examine APC activity in oocytes, noted...
17.
Yun Y, Lane S, Jones K
Development
. 2013 Dec;
141(1):199-208.
PMID: 24346700
As women get older their oocytes become susceptible to chromosome mis-segregation. This generates aneuploid embryos, leading to increased infertility and birth defects. Here we examined the provenance of aneuploidy by...
18.
Jones K, Lane S
Development
. 2013 Aug;
140(18):3719-30.
PMID: 23981655
Mammalian oocytes are particularly error prone in segregating their chromosomes during their two meiotic divisions. This results in the creation of an embryo that has inherited the wrong number of...
19.
Holt J, Lane S, Jones K
Curr Top Dev Biol
. 2013 Jan;
102:207-26.
PMID: 23287034
Mammalian oocytes spend the majority of their lives in a dormant state, residing in primordial follicles. This arrest, most analogous to the G2 stage of the mitotic cell cycle division,...
20.
Merriman J, Lane S, Holt J, Jennings P, Garcia-Higuera I, Moreno S, et al.
Biol Reprod
. 2012 Dec;
88(2):31.
PMID: 23255336
It is becoming clear that reduced chromosome cohesion is an important factor in the rise of maternal age-related aneuploidy. This reduction in cohesion has been observed both in human and...