Simon E Alfred
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Explore the profile of Simon E Alfred including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
1424
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0
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Recent Articles
1.
Labeling Using a Clickable ER-Disrupting Probe Suggests a Role for Oleosins in Seedling ER Integrity
Dejonghe W, Vaidya A, Alfred S, Cutler S
ACS Chem Biol
. 2021 Sep;
16(11):2151-2157.
PMID: 34505514
Several small-molecule perturbagens of the plant endomembrane system are known, but few selectively disrupt endoplasmic reticulum (ER) structure and function. We conducted a microscopy-based screen for small-molecule disruptors of ER...
2.
Merico D, Costain G, Butcher N, Warnica W, Ogura L, Alfred S, et al.
Front Neurol
. 2014 Dec;
5:238.
PMID: 25484875
The role of microRNAs (miRNAs) in the etiology of schizophrenia is increasingly recognized. Microdeletions at chromosome 22q11.2 are recurrent structural variants that impart a high risk for schizophrenia and are...
3.
Warnica W, Merico D, Costain G, Alfred S, Wei J, Marshall C, et al.
Biol Psychiatry
. 2014 Jul;
77(2):158-66.
PMID: 25034949
Background: MicroRNAs (miRNAs) are key regulators of gene expression in the human genome and may contribute to risk for neuropsychiatric disorders. miRNAs play an acknowledged role in the strongest of...
4.
Alfred S, Surendra A, Le C, Lin K, Mok A, Wallace I, et al.
Genome Biol
. 2012 Nov;
13(11):R105.
PMID: 23158586
Chemical biology, the interfacial discipline of using small molecules as probes to investigate biology, is a powerful approach of developing specific, rapidly acting tools that can be applied across organisms....
5.
Park S, Fung P, Nishimura N, Jensen D, Fujii H, Zhao Y, et al.
Science
. 2009 May;
324(5930):1068-71.
PMID: 19407142
Type 2C protein phosphatases (PP2Cs) are vitally involved in abscisic acid (ABA) signaling. Here, we show that a synthetic growth inhibitor called pyrabactin functions as a selective ABA agonist. Pyrabactin...
6.
Vincent J, Noor A, Windpassinger C, Gianakopoulos P, Schwarzbraun T, Alfred S, et al.
Am J Med Genet B Neuropsychiatr Genet
. 2008 Dec;
150B(6):817-26.
PMID: 19086034
We have recently reported the identification of a de novo balanced translocation t(5;18)(q33.1;q12.1) in a boy with autism. Here we discuss the identification of the breakpoints on chromosomes 5 and...
7.
Zhao Y, Chow T, Puckrin R, Alfred S, Korir A, Larive C, et al.
Nat Chem Biol
. 2007 Sep;
3(11):716-21.
PMID: 17891152
Natural variation in human drug metabolism and target genes can cause pharmacogenetic or interindividual variation in drug sensitivity. We reasoned that natural pharmacogenetic variation in model organisms could be systematically...
8.
Harvey C, Menon S, Stachowiak B, Noor A, Proctor A, Mensah A, et al.
Am J Med Genet B Neuropsychiatr Genet
. 2006 Dec;
144B(3):355-60.
PMID: 17171659
A new splice variant of the Rett syndrome gene, MECP2, was recently identified, that includes coding sequence from exon 1, and is the predominant transcript in the central nervous system....
9.
Mnatzakanian G, Lohi H, Munteanu I, Alfred S, Yamada T, MacLeod P, et al.
Nat Genet
. 2004 Mar;
36(4):339-41.
PMID: 15034579
Rett syndrome is caused by mutations in the gene MECP2 in approximately 80% of affected individuals. We describe a previously unknown MeCP2 isoform. Mutations unique to this isoform and the...