Simon Bohleber
Overview
Explore the profile of Simon Bohleber including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
122
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Recent Articles
1.
Ludwig C, Bohleber S, Lapp R, Rebl A, Wirth E, Langhammer M, et al.
J Ovarian Res
. 2023 Feb;
16(1):32.
PMID: 36739419
The development and maturation of ovarian follicles is a complex and highly regulated process, which is essential for successful ovulation. During recent decades, several mouse models provided insights into the...
2.
Bohleber S, Fradejas-Villar N, Zhao W, Reuter U, Schweizer U
Biomolecules
. 2022 Oct;
12(10).
PMID: 36291713
Co-translational incorporation of selenocysteine (Sec) into selenoproteins occurs at UGA codons in a process in which translational elongation competes with translational termination. Selenocysteine insertion sequence-binding protein 2 () greatly enhances...
3.
Ludwig C, Bohleber S, Rebl A, Wirth E, Venuto M, Langhammer M, et al.
J Mol Endocrinol
. 2022 Apr;
69(1):285-298.
PMID: 35388794
The Dummerstorf high-fertility mouse line FL1 is a worldwide unique selection experiment for increased female reproductive performance. After more than 190 generations of selection, these mice doubled the amount of...
4.
Braun D, Bohleber S, Vatine G, Svendsen C, Schweizer U
Thyroid
. 2022 Mar;
32(7):860-870.
PMID: 35357974
Monocarboxylate transporter 8 (MCT8) deficiency is a rare genetic disease leading to a severe developmental delay due to a lack of thyroid hormones (THs) during critical stages of human brain...
5.
Fradejas-Villar N, Zhao W, Reuter U, Doengi M, Ingold I, Bohleber S, et al.
Redox Biol
. 2021 Nov;
48:102188.
PMID: 34794077
Selenoproteins are a small family of proteins containing the trace element selenium in form of the rare amino acid selenocysteine (Sec), which is decoded by the UGA codon. In humans,...
6.
Fradejas-Villar N, Bohleber S, Zhao W, Reuter U, Kotter A, Helm M, et al.
Int J Mol Sci
. 2021 Nov;
22(21).
PMID: 34768885
Transfer RNA carries multiple post-transcriptional modifications. The A37G mutation in tRNA abrogates isopentenylation of base 37 and has a profound effect on selenoprotein expression in mice. Patients with a homozygous...
7.
Schweizer U, Bohleber S, Zhao W, Fradejas-Villar N
Front Neurosci
. 2021 Mar;
15:652099.
PMID: 33732108
Eighteen years ago, unexpected epileptic seizures in -knockout mice pointed to a potentially novel, possibly underestimated, and previously difficult to study role of selenium (Se) in the mammalian brain. This...
8.
Zhao W, Bohleber S, Schmidt H, Seeher S, Howard M, Braun D, et al.
J Biol Chem
. 2019 Jul;
294(39):14185-14200.
PMID: 31350336
Recoding of UGA codons as selenocysteine (Sec) codons in selenoproteins depends on a selenocysteine insertion sequence (SECIS) in the 3'-UTR of mRNAs of eukaryotic selenoproteins. SECIS-binding protein 2 (SECISBP2) increases...
9.
Schweizer U, Bohleber S, Fradejas-Villar N
RNA Biol
. 2017 Mar;
14(9):1197-1208.
PMID: 28277934
Base 37 in tRNA, 3'-adjacent to the anticodon, is occupied by a purine base that is thought to stabilize codon recognition by stacking interactions on the first Watson-Crick base pair....