Simon Anderhub
Overview
Explore the profile of Simon Anderhub including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
219
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0
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Recent Articles
1.
Steeneck C, Kinzel O, Anderhub S, Hornberger M, Pinto S, Morschhaeuser B, et al.
Bioorg Med Chem Lett
. 2020 Dec;
33:127744.
PMID: 33333163
Since the advent of antibody checkpoint inhibitors as highly efficient drugs for cancer treatment, the development of immunomodulating small molecules in oncology has gained great attention. Drug candidates targeting IDO1,...
2.
Kinzel O, Steeneck C, Anderhub S, Hornberger M, Pinto S, Morschhaeuser B, et al.
Bioorg Med Chem Lett
. 2020 Dec;
33:127738.
PMID: 33316404
Through structural modification of an oxalamide derived chemotype, a novel class of highly potent, orally bioavailable IDO1-specific inhibitors was identified. Representative compound 18 inhibited human IDO1 with IC values of...
3.
Steeneck C, Kinzel O, Anderhub S, Hornberger M, Pinto S, Morschhaeuser B, et al.
ACS Med Chem Lett
. 2020 Feb;
11(2):179-187.
PMID: 32071686
Following the impressive success of checkpoint inhibitors in the treatment of cancer, combinations of IDO1 inhibitors with PD-1/PD-L1 antibodies are in clinical development aiming to increase response rates. Using the...
4.
Keuser B, Khobta A, Galle K, Anderhub S, Schulz I, Pauly K, et al.
Mutagenesis
. 2013 Jul;
28(5):569-76.
PMID: 23814181
Accessibility of DNA is a prerequisite for both DNA damage and repair. Therefore, the chromatin structure is expected to have major impact on both processes, with opposite consequences for the...
5.
Maier B, Kirsch M, Anderhub S, Zentgraf H, Kramer A
Cell Cycle
. 2013 Apr;
12(9):1457-71.
PMID: 23574715
Accurate mitotic spindle positioning is essential for the regulation of cell fate choices, cell size and cell position within tissues. The most prominent model of spindle positioning involves a cortical...
6.
Raab M, Breitkreutz I, Anderhub S, Ronnest M, Leber B, Larsen T, et al.
Cancer Res
. 2012 Sep;
72(20):5374-85.
PMID: 22942257
In contrast to normal cells, malignant cells are frequently aneuploid and contain multiple centrosomes. To allow for bipolar mitotic division, supernumerary centrosomes are clustered into two functional spindle poles in...
7.
Ronnest M, Raab M, Anderhub S, Boesen S, Kramer A, Larsen T, et al.
J Med Chem
. 2011 Dec;
55(2):652-60.
PMID: 22191585
Griseofulvin and 53 analogues of this compound have been tested against the pathogenic dermatophytes Trichophyton rubrum and Trichophyton mentagrophytes as well as against the breast cancer cell line MDA-MB-231. The...
8.
Leber B, Maier B, Fuchs F, Chi J, Riffel P, Anderhub S, et al.
Sci Transl Med
. 2010 May;
2(33):33ra38.
PMID: 20505215
Current cancer chemotherapies are limited by the lack of tumor-specific targets, which would allow for selective eradication of malignant cells without affecting healthy tissues. In contrast to normal cells, most...
9.
Khobta A, Anderhub S, Kitsera N, Epe B
Nucleic Acids Res
. 2010 Mar;
38(13):4285-95.
PMID: 20338881
Oxidized DNA bases, particularly 7,8-dihydro-8-oxoguanine (8-oxoG), are endogenously generated in cells, being a cause of carcinogenic mutations and possibly interfering with gene expression. We found that expression of an oxidatively...