Siming Ma
Overview
Explore the profile of Siming Ma including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
2033
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Recent Articles
1.
Chen J, Kaya N, Zhang Y, Kendarsari R, Sekar K, Lee Chong S, et al.
J Hepatol
. 2024 May;
81(4):667-678.
PMID: 38782118
Background & Aims: Hepatocellular carcinoma (HCC) is a highly fatal cancer characterized by high intra-tumor heterogeneity (ITH). A panoramic understanding of its tumor evolution, in relation to its clinical trajectory,...
2.
Dan C, Cui Y, Wu Y, Chen Z, Liu H, Ji G, et al.
Nat Mater
. 2023 Aug;
22(10):1182-1188.
PMID: 37592031
Since the first discovery of the fatigue phenomenon in the late 1830s, efforts to fight against fatigue failure have continued. Here we report a fatigue resistance phenomenon in nano-TiB-decorated AlSi10Mg...
3.
Tyshkovskiy A, Ma S, Shindyapina A, Tikhonov S, Lee S, Bozaykut P, et al.
Cell
. 2023 Jun;
186(13):2929-2949.e20.
PMID: 37269831
Lifespan varies within and across species, but the general principles of its control remain unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species, identifying longevity signatures and examining...
4.
Phua C, Zhao X, Turcios-Hernandez L, McKernan M, Abyadeh M, Ma S, et al.
Geroscience
. 2023 Apr;
45(4):2161-2178.
PMID: 37086368
Altered mitochondrial function is tightly linked to lifespan regulation, but underlying mechanisms remain unclear. Here, we report the chronological and replicative lifespan variation across 167 yeast knock-out strains, each lacking...
5.
Tang J, Zhu J, Shu L, Huang X, Ma S
Comput Intell Neurosci
. 2022 Sep;
2022:8005538.
PMID: 36072716
Objective: The study aimed to investigate the relationship between human leukocyte antigen (HLA-DQB1) gene variants and recurrent miscarriage. Methods: HLA-DQ gene polymorphisms (PCR-SSP) were detected in 50 couples with recurrent...
6.
Fehlings M, Kim L, Guan X, Yuen K, Tafazzol A, Sanjabi S, et al.
J Immunother Cancer
. 2022 Aug;
10(8).
PMID: 35981786
Background: A growing body of evidence suggests that T-cell responses against neoantigens are critical regulators of response to immune checkpoint blockade. We previously showed that circulating neoantigen-specific CD8 T cells...
7.
Zhai W, Lai H, Kaya N, Chen J, Yang H, Lu B, et al.
Natl Sci Rev
. 2022 Apr;
9(3):nwab192.
PMID: 35382356
Intra-tumor heterogeneity (ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic (transcriptomic and immune) heterogeneity. Using one of...
8.
Nguyen P, Wasser M, Tan C, Lim C, Lai H, Seow J, et al.
Nat Commun
. 2022 Mar;
13(1):1441.
PMID: 35301339
Immune evasion is key to cancer initiation and later at metastasis, but its dynamics at intermediate stages, where potential therapeutic interventions could be applied, is undefined. Here we show, using...
9.
Kaya A, Phua C, Lee M, Wang L, Tyshkovskiy A, Ma S, et al.
Elife
. 2021 Nov;
10.
PMID: 34751131
To understand the genetic basis and selective forces acting on longevity, it is useful to examine lifespan variation among closely related species, or ecologically diverse isolates of the same species,...
10.
Loo S, Toh L, Xie W, Pathak E, Tan W, Ma S, et al.
Sci Adv
. 2021 Oct;
7(41):eabh2443.
PMID: 34613780
Cell state transitions control the functional behavior of cancer cells. Epithelial-to-mesenchymal transition (EMT) confers cancer stem cell-like properties, enhanced tumorigenicity and drug resistance to tumor cells, while mesenchymal-epithelial transition (MET)...