Simeon Springer
Overview
Explore the profile of Simeon Springer including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
2838
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0
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Recent Articles
1.
Arze C, Springer S, Dudas G, Patel S, Bhattacharyya A, Swaminathan H, et al.
Cell Host Microbe
. 2021 Jul;
29(8):1305-1315.e6.
PMID: 34320399
Anelloviruses are a ubiquitous component of healthy human viromes and remain highly prevalent after being acquired early in life. The full extent of "anellome" diversity and its evolutionary dynamics remain...
2.
Springer S, Masica D, Dal Molin M, Douville C, Thoburn C, Afsari B, et al.
Sci Transl Med
. 2019 Jul;
11(501).
PMID: 31316009
Pancreatic cysts are common and often pose a management dilemma, because some cysts are precancerous, whereas others have little risk of developing into invasive cancers. We used supervised machine learning...
3.
Fischer C, Beleva Guthrie V, Braxton A, Zheng L, Wang P, Song Q, et al.
Gastroenterology
. 2019 Jun;
157(4):1123-1137.e22.
PMID: 31175866
Background & Aims: Intraductal papillary mucinous neoplasms (IPMNs) are lesions that can progress to invasive pancreatic cancer and constitute an important system for studies of pancreatic tumorigenesis. We performed comprehensive...
4.
Wang Y, Li L, Douville C, Cohen J, Yen T, Kinde I, et al.
Sci Transl Med
. 2018 Mar;
10(433).
PMID: 29563323
We report the detection of endometrial and ovarian cancers based on genetic analyses of DNA recovered from the fluids obtained during a routine Papanicolaou (Pap) test. The new test, called...
5.
Douville C, Springer S, Kinde I, Cohen J, Hruban R, Lennon A, et al.
Proc Natl Acad Sci U S A
. 2018 Feb;
115(8):1871-1876.
PMID: 29432176
Aneuploidy is a feature of most cancer cells, and a myriad of approaches have been developed to detect it in clinical samples. We previously described primers that could be used...
6.
Pena M, Tregnago A, Eich M, Springer S, Wang Y, Taheri D, et al.
Virchows Arch
. 2017 Jun;
471(6):761-767.
PMID: 28597078
Our group and others have previously demonstrated the presence of TERT promoter mutations (TERT-mut) in 60-80% of urothelial carcinomas and some of their histologic variants. Five other genes have been...
7.
Mattox A, Wang Y, Springer S, Cohen J, Yegnasubramanian S, Nelson W, et al.
Proc Natl Acad Sci U S A
. 2017 Apr;
114(18):4733-4738.
PMID: 28416672
The identification of mutations that are present at low frequencies in clinical samples is an essential component of precision medicine. The development of molecular barcoding for next-generation sequencing has greatly...
8.
Nguyen D, Taheri D, Springer S, Cowan M, Guner G, Mendoza Rodriguez M, et al.
Virchows Arch
. 2016 Aug;
469(4):427-34.
PMID: 27520411
Somatic activating mutations in the promoter of the telomerase reverse transcriptase (TERT) gene are the most common genetic alterations in urothelial carcinoma (UC) of the bladder and upper urinary tract....
9.
Wang Y, Sundfeldt K, Mateoiu C, Shih I, Kurman R, Schaefer J, et al.
Elife
. 2016 Jul;
5.
PMID: 27421040
We determined whether the mutations found in ovarian cancers could be identified in the patients' ovarian cyst fluids. Tumor-specific mutations were detectable in the cyst fluids of 19 of 23...
10.
Tie J, Wang Y, Tomasetti C, Li L, Springer S, Kinde I, et al.
Sci Transl Med
. 2016 Jul;
8(346):346ra92.
PMID: 27384348
Detection of circulating tumor DNA (ctDNA) after resection of stage II colon cancer may identify patients at the highest risk of recurrence and help inform adjuvant treatment decisions. We used...