Silvia Taramino
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Explore the profile of Silvia Taramino including associated specialties, affiliations and a list of published articles.
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8
Citations
21
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Recent Articles
1.
Ferrante T, Barge A, Taramino S, Oliaro-Bosso S, Balliano G
Lipids
. 2016 Jul;
51(9):1103-13.
PMID: 27421732
Studies in the post-squalene section of sterol biosynthesis may be hampered by the poor availability of authentic standards. The present study used different yeast strains engineered in 3-ketosteroid reductase (Erg27p)...
2.
Layer J, Barnes B, Yamasaki Y, Barbuch R, Li L, Taramino S, et al.
Biochim Biophys Acta
. 2012 Oct;
1831(2):361-9.
PMID: 23022663
In yeast, deletion of ERG27, which encodes the sterol biosynthetic enzyme, 3-keto-reductase, results in a concomitant loss of the upstream enzyme, Erg7p, an oxidosqualene cyclase (OSC). However, this phenomenon occurs...
3.
Oliaro-Bosso S, Caron G, Taramino S, Ermondi G, Viola F, Balliano G
PLoS One
. 2011 Aug;
6(7):e22134.
PMID: 21811565
In oxidosqualene cyclases (OSCs), an enzyme which has been extensively studied as a target for hypocholesterolemic or antifungal drugs, a lipophilic channel connects the surface of the protein with the...
4.
Taramino S, Teske B, Oliaro-Bosso S, Bard M, Balliano G
Biochim Biophys Acta
. 2010 Jul;
1801(11):1232-7.
PMID: 20659585
In mammals and yeasts, oxidosqualene cyclase (OSC) catalyzes the formation of lanosterol, the first cyclic intermediate in sterol biosynthesis. We used a murine myeloma cell line (NS0), deficient in the...
5.
Balliano G, Dehmlow H, Oliaro-Bosso S, Scaldaferri M, Taramino S, Viola F, et al.
Bioorg Med Chem Lett
. 2009 Jan;
19(3):718-23.
PMID: 19119009
A series of 25 compounds, some of which previously were described as inhibitors of human liver microsomal oxidosqualene cyclase (OSC), were tested as inhibitors of Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis...
6.
Oliaro-Bosso S, Taramino S, Viola F, Tagliapietra S, Ermondi G, Cravotto G, et al.
J Enzyme Inhib Med Chem
. 2008 Oct;
24(2):589-98.
PMID: 18830877
Human and murine lanosterol synthases (EC 5.4.99.7) were studied as targets of a series of umbelliferone aminoalkyl derivatives previously tested as inhibitors of oxidosqualene cyclases from other eukaryotes. Tests were...
7.
Oliaro-Bosso S, Viola F, Taramino S, Tagliapietra S, Barge A, Cravotto G, et al.
ChemMedChem
. 2006 Dec;
2(2):226-33.
PMID: 17154325
Eighteen coumarin derivatives were tested as inhibitors of oxidosqualene cyclases (OSCs) from Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis carinii, Homo sapiens, and Arabidopsis thaliana, all expressed in an OSC-defective strain of...
8.
Galli U, Oliaro-Bosso S, Taramino S, Venegoni S, Pastore E, Tron G, et al.
Bioorg Med Chem Lett
. 2006 Oct;
17(1):220-4.
PMID: 17027267
New dimethylamino truncated squalene ether derivatives containing a different aromatic moiety (phenyl, naphthyl, and biphenyl) or a simple alkyl (n-hexylic) group were synthesized as inhibitors of the oxidosqualene cyclase (OSC)...