Silvia Innocentin
Overview
Explore the profile of Silvia Innocentin including associated specialties, affiliations and a list of published articles.
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24
Citations
1080
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Recent Articles
1.
Lee J, Innocentin S, Silva-Cayetano A, Guillaume S, Linterman M
J Immunol
. 2023 Sep;
211(10):1506-1515.
PMID: 37756528
Affinity maturation, the progressive increase in serum Ab affinity after vaccination, is an essential process that contributes to an effective humoral response against vaccines and infections. Germinal centers are key...
2.
Silva-Cayetano A, Fra-Bido S, Robert P, Innocentin S, Burton A, Watson E, et al.
Nat Immunol
. 2023 May;
24(7):1124-1137.
PMID: 37217705
The magnitude and quality of the germinal center (GC) response decline with age, resulting in poor vaccine-induced immunity in older individuals. A functional GC requires the co-ordination of multiple cell...
3.
van der Klaauw A, Horner E, Pereyra-Gerber P, Agrawal U, Foster W, Spencer S, et al.
Nat Med
. 2023 May;
29(5):1146-1154.
PMID: 37169862
Obesity is associated with an increased risk of severe Coronavirus Disease 2019 (COVID-19) infection and mortality. COVID-19 vaccines reduce the risk of serious COVID-19 outcomes; however, their effectiveness in people...
4.
Foster W, Lee J, Thakur N, Newman J, Spencer A, Davies S, et al.
Cell Rep Med
. 2022 Dec;
3(12):100845.
PMID: 36455555
Emergence from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been facilitated by the rollout of effective vaccines. Successful vaccines generate high-affinity plasma blasts and long-lived protective memory...
5.
Lee J, Fra-Bido S, Burton A, Innocentin S, Hill D, Linterman M
Aging Cell
. 2022 Aug;
21(9):e13692.
PMID: 35980826
Vaccines typically protect against (re)infections by generating pathogen-neutralising antibodies. However, as we age, antibody-secreting cell formation and vaccine-induced antibody titres are reduced. Antibody-secreting plasma cells differentiate from B cells either...
6.
Denton A, Dooley J, Cinti I, Silva-Cayetano A, Fra-Bido S, Innocentin S, et al.
Sci Immunol
. 2022 May;
7(71):eabk0018.
PMID: 35522725
The failure to generate enduring humoral immunity after vaccination is a hallmark of advancing age. This can be attributed to a reduction in the germinal center (GC) response, which generates...
7.
Hill D, Whyte C, Innocentin S, Lee J, Dooley J, Wang J, et al.
Elife
. 2021 Nov;
10.
PMID: 34726156
Antibody production following vaccination can provide protective immunity to subsequent infection by pathogens such as influenza viruses. However, circumstances where antibody formation is impaired after vaccination, such as in older...
8.
Fra-Bido S, Walker S, Innocentin S, Linterman M
STAR Protoc
. 2021 Jul;
2(3):100499.
PMID: 34195671
Location of immune cells that form the germinal center reaction within secondary lymphoid tissues can be characterized using confocal microscopy. Here, we present an optimized immunofluorescence staining protocol to image...
9.
Silva-Cayetano A, Foster W, Innocentin S, Belij-Rammerstorfer S, Spencer A, Burton O, et al.
Med
. 2021 Feb;
2(3):243-262.e8.
PMID: 33521747
Background: The spread of SARS-CoV-2 has caused a worldwide pandemic that has affected almost every aspect of human life. The development of an effective COVID-19 vaccine could limit the morbidity...
10.
Webb L, Fra-Bido S, Innocentin S, Matheson L, Attaf N, Bignon A, et al.
Aging Cell
. 2021 Jan;
20(1):e13295.
PMID: 33387451
Ageing profoundly changes our immune system and is thought to be a driving factor in the morbidity and mortality associated with infectious disease in older people. We have previously shown...