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Danika L Hill

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Articles 26
Citations 532
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Recent Articles
1.
Osowicki J, Frost H, Azzopardi K, Whitcombe A, McGregor R, Carlton L, et al.
Nat Commun . 2024 Dec; 15(1):10506. PMID: 39627204
Knowledge gaps regarding human immunity to Streptococcus pyogenes have impeded vaccine development. To address these gaps and evaluate vaccine candidates, we established a human challenge model of S. pyogenes pharyngitis....
2.
Dvorscek A, McKenzie C, Staheli V, Ding Z, White J, Fabb S, et al.
Immunity . 2024 Sep; 57(10):2433-2452.e7. PMID: 39305904
Existing antibodies (Abs) have varied effects on humoral immunity during subsequent infections. Here, we leveraged in vivo systems that allow precise control of antigen-specific Abs and B cells to examine...
3.
Ding Z, Hagan M, Yan F, Schroer N, Polmear J, Good-Jacobson K, et al.
J Exp Med . 2024 Jun; 221(8). PMID: 38842525
The proliferation marker Ki67 has been attributed critical functions in maintaining mitotic chromosome morphology and heterochromatin organization during the cell cycle, indicating a potential role in developmental processes requiring rigid...
4.
Burton A, Guillaume S, Foster W, Wheatley A, Hill D, Carr E, et al.
Cell Rep . 2024 Jan; 43(2):113745. PMID: 38281131
No abstract available.
5.
Silva-Cayetano A, Fra-Bido S, Robert P, Innocentin S, Burton A, Watson E, et al.
Nat Immunol . 2023 May; 24(7):1124-1137. PMID: 37217705
The magnitude and quality of the germinal center (GC) response decline with age, resulting in poor vaccine-induced immunity in older individuals. A functional GC requires the co-ordination of multiple cell...
6.
Robinson M, Ding Z, Dowling M, Hill D, Webster R, McKenzie C, et al.
Immunity . 2023 May; 56(7):1596-1612.e4. PMID: 37164016
Antibodies produced by antibody-secreting plasma cells (ASCs) underlie multiple forms of long-lasting immunity. Here we examined the mechanisms regulating ASC turnover and persistence using a genetic reporter to time-stamp ASCs....
7.
Bonaud A, Gargowitsch L, Gilbert S, Rajan E, Canales-Herrerias P, Stockholm D, et al.
Proc Natl Acad Sci U S A . 2023 Jan; 120(2):e2213056120. PMID: 36595686
Despite the essential role of plasma cells in health and disease, the cellular mechanisms controlling their survival and secretory capacity are still poorly understood. Here, we identified the soluble N-ethylmaleimide-sensitive...
8.
Burton A, Guillaume S, Foster W, Wheatley A, Hill D, Carr E, et al.
Cell Rep . 2022 Nov; 41(6):111613. PMID: 36351385
Influenza infection imparts an age-related increase in mortality and morbidity. The most effective countermeasure is vaccination; however, vaccines offer modest protection in older adults. To investigate how aging impacts the...
9.
Robinson M, Dowling M, Pitt C, ODonnell K, Webster R, Hill D, et al.
Sci Immunol . 2022 Oct; 7(76):eabm8389. PMID: 36306370
Vaccines work largely by generating long-lived plasma cells (LLPCs), but knowledge of how such cells are recruited is sparse. Although it is clear that LLPCs preferentially originate in germinal centers...
10.
Lee J, Fra-Bido S, Burton A, Innocentin S, Hill D, Linterman M
Aging Cell . 2022 Aug; 21(9):e13692. PMID: 35980826
Vaccines typically protect against (re)infections by generating pathogen-neutralising antibodies. However, as we age, antibody-secreting cell formation and vaccine-induced antibody titres are reduced. Antibody-secreting plasma cells differentiate from B cells either...