Alyssa Silva-Cayetano
Overview
Explore the profile of Alyssa Silva-Cayetano including associated specialties, affiliations and a list of published articles.
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8
Citations
348
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Recent Articles
1.
Lee J, Innocentin S, Silva-Cayetano A, Guillaume S, Linterman M
J Immunol
. 2023 Sep;
211(10):1506-1515.
PMID: 37756528
Affinity maturation, the progressive increase in serum Ab affinity after vaccination, is an essential process that contributes to an effective humoral response against vaccines and infections. Germinal centers are key...
2.
Silva-Cayetano A, Fra-Bido S, Robert P, Innocentin S, Burton A, Watson E, et al.
Nat Immunol
. 2023 May;
24(7):1124-1137.
PMID: 37217705
The magnitude and quality of the germinal center (GC) response decline with age, resulting in poor vaccine-induced immunity in older individuals. A functional GC requires the co-ordination of multiple cell...
3.
Denton A, Dooley J, Cinti I, Silva-Cayetano A, Fra-Bido S, Innocentin S, et al.
Sci Immunol
. 2022 May;
7(71):eabk0018.
PMID: 35522725
The failure to generate enduring humoral immunity after vaccination is a hallmark of advancing age. This can be attributed to a reduction in the germinal center (GC) response, which generates...
4.
Silva-Cayetano A, Foster W, Innocentin S, Belij-Rammerstorfer S, Spencer A, Burton O, et al.
Med
. 2021 Feb;
2(3):243-262.e8.
PMID: 33521747
Background: The spread of SARS-CoV-2 has caused a worldwide pandemic that has affected almost every aspect of human life. The development of an effective COVID-19 vaccine could limit the morbidity...
5.
Silva-Cayetano A, Linterman M
Curr Opin Immunol
. 2020 Apr;
64:26-33.
PMID: 32325390
The germinal centre (GC) is a specialized cellular structure that forms in response to antigenic stimulation. It generates long-term humoral immunity through the production of memory B cells and long-lived...
6.
Stebegg M, Bignon A, Hill D, Silva-Cayetano A, Krueger C, Vanderleyden I, et al.
Elife
. 2020 Mar;
9.
PMID: 32204792
Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in response to vaccination, producing long-lived antibody secreting plasma cells and memory B cells that protect against subsequent...
7.
Stebegg M, Silva-Cayetano A, Innocentin S, Jenkins T, Cantacessi C, Gilbert C, et al.
Nat Commun
. 2019 Jun;
10(1):2443.
PMID: 31164642
Ageing is a complex multifactorial process associated with a plethora of disorders, which contribute significantly to morbidity worldwide. One of the organs significantly affected by age is the gut. Age-dependent...
8.
Stebegg M, Kumar S, Silva-Cayetano A, Fonseca V, Linterman M, Graca L
Front Immunol
. 2018 Nov;
9:2469.
PMID: 30410492
The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can provide protection against reinfection....