Silvia Bonas-Guarch
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Explore the profile of Silvia Bonas-Guarch including associated specialties, affiliations and a list of published articles.
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23
Citations
1524
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Recent Articles
1.
Huerta-Chagoya A, Schroeder P, Mandla R, Li J, Morris L, Vora M, et al.
Nat Genet
. 2024 Oct;
56(11):2576.
PMID: 39438755
No abstract available.
2.
Huerta-Chagoya A, Schroeder P, Mandla R, Li J, Morris L, Vora M, et al.
Nat Genet
. 2024 Oct;
56(11):2370-2379.
PMID: 39379762
Type 2 diabetes (T2D) genome-wide association studies (GWASs) often overlook rare variants as a result of previous imputation panels' limitations and scarce whole-genome sequencing (WGS) data. We used TOPMed imputation...
3.
Hu M, Kim I, Moran I, Peng W, Sun O, Bonnefond A, et al.
FASEB J
. 2024 Apr;
38(8):e23610.
PMID: 38661000
Variants at the SLC30A8 locus are associated with type 2 diabetes (T2D) risk. The lead variant, rs13266634, encodes an amino acid change, Arg325Trp (R325W), at the C-terminus of the secretory...
4.
Hu M, Kim I, Moran I, Peng W, Sun O, Bonnefond A, et al.
bioRxiv
. 2023 Jul;
PMID: 37502937
Variants at the locus are associated with type 2 diabetes (T2D) risk. The lead variant, rs13266634, encodes an amino acid change, Arg325Trp (R325W), at the C-terminus of the secretory granule-enriched...
5.
Juan-Mateu J, Bajew S, Miret-Cuesta M, Iniguez L, Lopez-Pascual A, Bonnal S, et al.
Nat Metab
. 2023 Feb;
5(2):219-236.
PMID: 36759540
Pancreatic islets control glucose homeostasis by the balanced secretion of insulin and other hormones, and their abnormal function causes diabetes or hypoglycaemia. Here we uncover a conserved programme of alternative...
6.
Atla G, Bonas-Guarch S, Cuenca-Ardura M, Beucher A, Crouch D, Garcia-Hurtado J, et al.
Genome Biol
. 2022 Sep;
23(1):196.
PMID: 36109769
Background: Non-coding genetic variants that influence gene transcription in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D), and likely also contribute to type 1...
7.
OConnor M, Schroeder P, Huerta-Chagoya A, Cortes-Sanchez P, Bonas-Guarch S, Guindo-Martinez M, et al.
Diabetes
. 2021 Dec;
71(3):554-565.
PMID: 34862199
Most genome-wide association studies (GWAS) of complex traits are performed using models with additive allelic effects. Hundreds of loci associated with type 2 diabetes have been identified using this approach....
8.
Alonso L, Piron A, Moran I, Guindo-Martinez M, Bonas-Guarch S, Atla G, et al.
Cell Rep
. 2021 Oct;
37(2):109807.
PMID: 34644572
Genome-wide association studies (GWASs) identified hundreds of signals associated with type 2 diabetes (T2D). To gain insight into their underlying molecular mechanisms, we have created the translational human pancreatic islet...
9.
Guindo-Martinez M, Amela R, Bonas-Guarch S, Puiggros M, Salvoro C, Miguel-Escalada I, et al.
Nat Commun
. 2021 Apr;
12(1):2436.
PMID: 33893285
Genome-wide association studies (GWAS) are not fully comprehensive, as current strategies typically test only the additive model, exclude the X chromosome, and use only one reference panel for genotype imputation....
10.
Bevacqua R, Dai X, Lam J, Gu X, Friedlander M, Tellez K, et al.
Nat Commun
. 2021 Apr;
12(1):2397.
PMID: 33893274
Gene targeting studies in primary human islets could advance our understanding of mechanisms driving diabetes pathogenesis. Here, we demonstrate successful genome editing in primary human islets using clustered regularly interspaced...