Siler H Panowski
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Explore the profile of Siler H Panowski including associated specialties, affiliations and a list of published articles.
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10
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805
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Recent Articles
1.
Lin R, Sutton J, Bentley T, Vargas-Inchaustegui D, Nguyen D, Cheng H, et al.
Sci Adv
. 2023 Aug;
9(31):eadg8694.
PMID: 37540748
The magnitude of CAR T cell expansion has been associated with clinical efficacy. Although cytokines can augment CAR T cell proliferation, systemically administered cytokines can result in toxicities. To gain...
2.
Zhang Y, Tacheva-Grigorova S, Sutton J, Melton Z, Mak Y, Lay C, et al.
Clin Cancer Res
. 2023 Jan;
29(5):971-985.
PMID: 36692420
Purpose: Small cell lung cancer (SCLC) is an aggressive disease with limited treatment options. Delta-like ligand 3 (DLL3) is highly expressed on SCLC and several other types of neuroendocrine cancers,...
3.
Lin R, Nager A, Park S, Sutton J, Lay C, Melton Z, et al.
Cancer Immunol Res
. 2022 Jul;
10(9):1069-1083.
PMID: 35881865
Although cytokine support can enhance CAR T-cell function, coadministering cytokines or engineering CAR T cells to secrete cytokines can result in toxicities. To mitigate these safety risks, we engineered iTurboCAR...
4.
Panowski S, Srinivasan S, Tan N, Tacheva-Grigorova S, Smith B, Mak Y, et al.
Cancer Res
. 2022 Mar;
82(14):2610-2624.
PMID: 35294525
Significance: These findings demonstrate the efficacy and safety of fratricide-resistant, allogeneic anti-CD70 CAR T cells targeting renal cell carcinoma and the impact of CAR epitope on functional activity. See related...
5.
Panowski S, Kuo T, Zhang Y, Chen A, Geng T, Aschenbrenner L, et al.
Mol Cancer Ther
. 2019 Aug;
18(11):2008-2020.
PMID: 31434693
The restricted expression pattern of B-cell maturation antigen (BCMA) makes it an ideal tumor-associated antigen (TAA) for the treatment of myeloma. BCMA has been targeted by both CD3 bispecific antibody...
6.
Kumsta C, Ching T, Nishimura M, Davis A, Gelino S, Catan H, et al.
Aging Cell
. 2013 Dec;
13(3):419-30.
PMID: 24314125
Integrin-signaling complexes play important roles in cytoskeletal organization and cell adhesion in many species. Components of the integrin-signaling complex have been linked to aging in both Caenorhabditis elegans and Drosophila...
7.
Panowski S, Dillin A
Trends Endocrinol Metab
. 2009 Aug;
20(6):259-64.
PMID: 19646896
Aging research has advanced greatly in the nematode Caenorhabditis elegans over the past 20 years, and we are now beginning to piece together distinct pathways that impinge on the aging...
8.
Mair W, Panowski S, Shaw R, Dillin A
PLoS One
. 2009 Feb;
4(2):e4535.
PMID: 19229346
Dietary restriction (DR) increases mammalian lifespan and decreases susceptibility to many age-related diseases. Lifespan extension due to DR is conserved across a wide range of species. Recent research has focused...
9.
DAngelo M, Raices M, Panowski S, Hetzer M
Cell
. 2009 Jan;
136(2):284-95.
PMID: 19167330
In dividing cells, nuclear pore complexes (NPCs) disassemble during mitosis and reassemble into the newly forming nuclei. However, the fate of nuclear pores in postmitotic cells is unknown. Here, we...
10.
Panowski S, Wolff S, Aguilaniu H, Durieux J, Dillin A
Nature
. 2007 May;
447(7144):550-5.
PMID: 17476212
Reduced food intake as a result of dietary restriction increases the lifespan of a wide variety of metazoans and delays the onset of multiple age-related pathologies. Dietary restriction elicits a...