Sigrid E M Heinsbroek
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Explore the profile of Sigrid E M Heinsbroek including associated specialties, affiliations and a list of published articles.
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21
Citations
666
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Recent Articles
1.
van Thiel I, Kreulen I, Benard M, de Goffau M, Theelen B, Heinsbroek S, et al.
Pathog Dis
. 2025 Jan;
83.
PMID: 39794285
Inflammatory diseases of the human gastrointestinal tract are affected by the microbes that reside in the mucosal surfaces. Patients with inflammatory bowel diseases (IBD) have altered bacterial and fungal intestinal...
2.
van Thiel I, Rahman S, Hakvoort T, Davids M, Verseijden C, van Hamersveld P, et al.
Microorganisms
. 2022 Apr;
10(4).
PMID: 35456788
Fecal microbiota transplantation (FMT) has the potential to restore (bacterial and fungal) microbial imbalance in ulcerative colitis (UC) patients and contribute to disease remission. Here, we aimed to identify fecal...
3.
van Thiel I, Stavrou A, de Jong A, Theelen B, Davids M, Hakvoort T, et al.
Sci Rep
. 2022 Mar;
12(1):5391.
PMID: 35354908
Irritable bowel syndrome (IBS) is a common disorder characterized by chronic abdominal pain and changes in bowel movements. Visceral hypersensitivity is thought to be responsible for pain complaints in a...
4.
Rahman S, Vandewalle J, van Hamersveld P, Verseijden C, Welting O, Jongejan A, et al.
Cells
. 2022 Jan;
11(1).
PMID: 35011620
Antimicrobial responses play an important role in maintaining intestinal heath. Recently we reported that miR-511 may regulate TLR4 responses leading to enhanced intestinal inflammation. However, the exact mechanism remained unclear....
5.
Elfiky A, Ghiboub M, Li Yim A, Hageman I, Verhoeff J, de Krijger M, et al.
J Crohns Colitis
. 2021 Oct;
16(4):668-681.
PMID: 34633041
Background And Aims: Histone deacetylase inhibitors [HDACi] exert potent anti-inflammatory effects. Because of the ubiquitous expression of HDACs, clinical utility of HDACi is limited by off-target effects. Esterase-sensitive motif [ESM]...
6.
Rahman S, Davids M, van Hamersveld P, Welting O, Rahaoui H, Schuren F, et al.
Nutrients
. 2021 Apr;
13(4).
PMID: 33920960
β-glucan consumption is known for its beneficial health effects, but the mode of action is unclear. While humans and mice lack the required enzymes to digest β-glucans, certain intestinal microbes...
7.
Diederen K, Li J, Donachie G, de Meij T, de Waart D, Hakvoort T, et al.
Sci Rep
. 2020 Nov;
10(1):18879.
PMID: 33144591
A nutritional intervention, exclusive enteral nutrition (EEN) can induce remission in patients with pediatric Crohn's disease (CD). We characterized changes in the fecal microbiota and metabolome to identify the mechanism...
8.
Botschuijver S, van Diest S, van Thiel I, Saia R, Strik A, Yu Z, et al.
Sci Rep
. 2019 Aug;
9(1):12530.
PMID: 31467355
Irritable bowel syndrome (IBS) is a heterogenic, functional gastrointestinal disorder of the gut-brain axis characterized by altered bowel habit and abdominal pain. Preclinical and clinical results suggested that, in part...
9.
Willemze R, Welting O, van Hamersveld P, Verseijden C, Nijhuis L, Hilbers F, et al.
Mol Med
. 2019 Jan;
25(1):1.
PMID: 30616543
Background: Both the parasympathetic and sympathetic nervous system exert control over innate immune responses. In inflammatory bowel disease, sympathetic innervation in intestinal mucosa is reduced. Our aim was to investigate...
10.
Botschuijver S, Roeselers G, Levin E, Jonkers D, Welting O, Heinsbroek S, et al.
Gastroenterology
. 2017 Jun;
153(4):1026-1039.
PMID: 28624575
Background & Aims: Visceral hypersensitivity is one feature of irritable bowel syndrome (IBS). Bacterial dysbiosis might be involved in the activation of nociceptive sensory pathways, but there have been few...