Siew Lee Cheong
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Explore the profile of Siew Lee Cheong including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
106
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Recent Articles
1.
Cheong S, Tiew J, Fong Y, Leong H, Chan Y, Chan Z, et al.
Pharmaceuticals (Basel)
. 2022 Dec;
15(12).
PMID: 36559010
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by decreased synaptic transmission and cerebral atrophy with appearance of amyloid plaques and neurofibrillary tangles. Cognitive, functional, and behavioral alterations are commonly...
2.
Chow Y, Yam H, Gunasekaran B, Lai W, Wo W, Agarwal T, et al.
Front Cell Infect Microbiol
. 2022 Oct;
12:987683.
PMID: 36250046
is a major pathogenic bacterium involved in the pathogenesis of periodontitis. Citrullination has been reported as the underlying mechanism of the pathogenesis, which relies on the interplay between two virulence...
3.
Tan S, Yam H, Cheong S, Chow Y, Bok C, Ho J, et al.
Saudi J Biol Sci
. 2022 May;
29(4):2573-2581.
PMID: 35531186
, the cause of periodontitis, is also linked to many systemic disorders due to its citrullination capability from a unique peptidyl arginine deiminase (PPAD). Protein citrullination is able to trigger...
4.
Tibon N, Ng C, Cheong S
Eur J Med Chem
. 2020 Jan;
188:111983.
PMID: 31911292
Discovery and development of antimalarial drugs have long been dominated by single-target therapy. Continuous effort has been made to explore and identify different targets in malaria parasite crucial for the...
5.
Tan A, Babak M, Venkatesan G, Lim C, Klotz K, Herr D, et al.
Molecules
. 2019 Oct;
24(20).
PMID: 31614517
Human A adenosine receptor hAAR has been implicated in gastrointestinal cancer, where its cellular expression has been found increased, thus suggesting its potential as a molecular target for novel anticancer...
6.
Shao Y, Ma X, Paira P, Tan A, Herr D, Lim K, et al.
PLoS One
. 2018 Jan;
13(1):e0188212.
PMID: 29304113
Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra of the human brain, leading to depletion of dopamine production. Dopamine replacement...
7.
Zhang C, Shao Y, Ma X, Cheong S, Qin C, Tao L, et al.
J Mol Graph Model
. 2017 Jul;
76:136-142.
PMID: 28728042
Conventional ligand and receptor similarity methods have been extensively used for exposing pharmacological relationships and drug lead discovery. They may in some cases neglect minor relationships useful for target hopping...
8.
Cheong S, Venkatesan G, Paira P, Jothibasu R, Mandel A, Federico S, et al.
Int J Med Chem
. 2015 May;
2011:480652.
PMID: 25954519
In the past few decades, medicinal chemistry research towards potent and selective antagonists of human adenosine receptors (namely, A1, A2A, A2B, and A3) has been evolving rapidly. These antagonists are...
9.
Venkatesan G, Paira P, Cheong S, Vamsikrishna K, Federico S, Klotz K, et al.
Bioorg Med Chem
. 2014 Feb;
22(5):1751-65.
PMID: 24518296
In the present study, a molecular simplification approach was employed to design novel bicyclic pyrazolo[3,4-d]pyrimidine (PP) derivatives from tricyclic pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidines (PTP) as promising human A3 adenosine receptor (hA3AR) antagonists. All...
10.
Paira P, Chow M, Venkatesan G, Kosaraju V, Cheong S, Klotz K, et al.
Chemistry
. 2013 Apr;
19(25):8321-30.
PMID: 23613215
Human A₃ adenosine receptor (A₃AR) is a membrane-bound G protein-coupled receptor implicated in a number of severe pathological conditions, including cancer, in which it acts as a potential therapeutic target....