Shimpei Kawamoto
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Explore the profile of Shimpei Kawamoto including associated specialties, affiliations and a list of published articles.
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30
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3201
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Recent Articles
1.
Mizuno H, Kawamoto S, Uemura K, Park J, Hori N, Okumura Y, et al.
Aging Cell
. 2024 Aug;
23(12):e14304.
PMID: 39123277
In recent years, there has been increasing attention towards understanding the relationship between age-related alterations in the oral microbiota and age-associated diseases, with reports emphasizing the significance of maintaining a...
2.
Kawamoto S, Hara E
Trends Cell Biol
. 2024 Jan;
34(8):626-635.
PMID: 38220548
Two phenomena, the accumulation of senescent cells and changes in the gut microbiota, are thought to contribute to the decline of biological functions and the development of diseases associated with...
3.
Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice
Endo T, Kobayashi K, Matsumura T, Emori C, Ozawa M, Kawamoto S, et al.
Commun Biol
. 2024 Jan;
7(1):16.
PMID: 38177279
In mammals, females undergo reproductive cessation with age, whereas male fertility gradually declines but persists almost throughout life. However, the detailed effects of ageing on germ cells during and after...
4.
Matsudaira T, Nakano S, Konishi Y, Kawamoto S, Uemura K, Kondo T, et al.
Commun Biol
. 2023 Jun;
6(1):665.
PMID: 37353538
Cellular senescence, a state of irreversible cell-cycle arrest caused by a variety of cellular stresses, is critically involved in age-related tissue dysfunction in various organs. However, the features of cells...
5.
Kawamoto S, Uemura K, Hori N, Takayasu L, Konishi Y, Katoh K, et al.
Nat Cell Biol
. 2023 May;
25(6):865-876.
PMID: 37169880
The elucidation of the mechanisms of ageing and the identification of methods to control it have long been anticipated. Recently, two factors associated with ageing-the accumulation of senescent cells and...
6.
Tsuji S, Minami S, Hashimoto R, Konishi Y, Suzuki T, Kondo T, et al.
Nat Aging
. 2023 Apr;
2(2):115-124.
PMID: 37117754
Reports of post-acute COVID-19 syndrome, in which the inflammatory response persists even after SARS-CoV-2 has disappeared, are increasing, but the underlying mechanisms of post-acute COVID-19 syndrome remain unknown. Here, we...
7.
Araki C, Takemoto D, Kitagawa Y, Tateishi N, Rogi T, Izumo T, et al.
Nutrients
. 2023 Apr;
15(7).
PMID: 37049468
Cellular senescence induces inflammation and is now considered one of the causes of organismal aging. Accumulating evidence indicates that age-related deterioration of mitochondrial function leads to an increase in reactive...
8.
Kawamoto S, Matsumoto T, Takasugi M, Hara E
Genes Cells
. 2022 Jun;
27(8):517-525.
PMID: 35726163
The 6th conference of the international cell senescence association (ICSA) on the theme of "A New Era of Senescence Research: The Challenge of Controlling Aging and Cancer" was held on...
9.
Okumura S, Konishi Y, Narukawa M, Sugiura Y, Yoshimoto S, Arai Y, et al.
Nat Commun
. 2021 Sep;
12(1):5674.
PMID: 34584098
Emerging evidence is revealing that alterations in gut microbiota are associated with colorectal cancer (CRC). However, very little is currently known about whether and how gut microbiota alterations are causally...
10.
Tanabe Y, Kawamoto S, Takaku T, Morishita S, Hirao A, Komatsu N, et al.
Blood Adv
. 2020 Dec;
4(24):6175-6188.
PMID: 33351113
BCR-ABL, an oncogenic fusion gene, plays a central role in the pathogenesis of chronic myeloid leukemia (CML). Oncogenic signaling induces oncogene-induced senescence and senescence-associated secretory phenotype (SASP), which is characterized...