Siddharth Sankar Singh
Overview
Explore the profile of Siddharth Sankar Singh including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
181
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Recent Articles
1.
Kumar S, Bhushan Chauhan S, Upadhyay S, Singh S, Verma V, Kumar R, et al.
PLoS Negl Trop Dis
. 2024 Feb;
18(2):e0011960.
PMID: 38408097
Background: CD4+ T cells play a central role in control of L. donovani infection, through IFN-γ production required for activation of macrophages and killing of intracellular parasites. Impaired control of...
2.
Ng S, De Labastida Rivera F, Yan J, Corvino D, Das I, Zhang P, et al.
Nat Immunol
. 2024 Feb;
25(4):716.
PMID: 38360937
No abstract available.
3.
Edwards C, Engel J, De Labastida Rivera F, Ng S, Corvino D, Montes de Oca M, et al.
JCI Insight
. 2023 Nov;
8(24).
PMID: 37917177
Control of visceral leishmaniasis (VL) depends on proinflammatory Th1 cells that activate infected tissue macrophages to kill resident intracellular parasites. However, proinflammatory cytokines produced by Th1 cells can damage tissues...
4.
Edwards C, Ng S, De Labastida Rivera F, Corvino D, Engel J, Montes de Oca M, et al.
J Clin Invest
. 2023 Feb;
133(4).
PMID: 36787259
No abstract available.
5.
Edwards C, Ng S, De Labastida Rivera F, Corvino D, Engel J, Montes de Oca M, et al.
J Clin Invest
. 2023 Jan;
133(1).
PMID: 36594463
Control of intracellular parasites responsible for malaria requires host IFN-γ+T-bet+CD4+ T cells (Th1 cells) with IL-10 produced by Th1 cells to mitigate the pathology induced by this inflammatory response. However,...
6.
Singh S, Bhushan Chauhan S, Ng S, Corvino D, De Labastida Rivera F, Engel J, et al.
Clin Transl Immunology
. 2022 Jun;
11(6):e1396.
PMID: 35663920
Objectives: There is an urgent need to be able to identify individuals with asymptomatic infection, so their risk of progressing to VL and transmitting parasites can be managed. This study...
7.
Kumar A, Singh B, Tiwari R, Singh V, Singh S, Sundar S, et al.
Infect Genet Evol
. 2022 Jan;
98:105210.
PMID: 35031509
γδ T cells are thymus derived heterogeneous and unconventional T- lymphocyte expressing TCR γ (V γ9) and TCRδ (Vδ2) chain and play an important role in connecting innate and adaptive...
8.
Ng S, De Labastida Rivera F, Yan J, Corvino D, Das I, Zhang P, et al.
Nat Immunol
. 2020 Aug;
21(10):1205-1218.
PMID: 32839608
Immune-modulating therapies have revolutionized the treatment of chronic diseases, particularly cancer. However, their success is restricted and there is a need to identify new therapeutic targets. Here, we show that...
9.
Kumar R, Bunn P, Singh S, Ng S, Montes de Oca M, De Labastida Rivera F, et al.
Cell Rep
. 2020 Feb;
30(8):2512-2525.e9.
PMID: 32101732
Type I interferons (IFNs) play critical roles in anti-viral and anti-tumor immunity. However, they also suppress protective immune responses in some infectious diseases. Here, we identify type I IFNs as...
10.
Singh B, Bhushan Chauhan S, Kumar R, Singh S, Ng S, Amante F, et al.
Parasite Immunol
. 2019 Sep;
41(11):e12669.
PMID: 31494954
CD8 T-cell function is compromised in chronic diseases such as visceral leishmaniasis (VL). However, little is known about the changes in gene expression that cause CD8+ T-cell dysfunction during VL....