Siao Ping Tsai
Overview
Explore the profile of Siao Ping Tsai including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
1315
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0
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Recent Articles
11.
Kozak K, Tsai S, Fourie-ODonohue A, Dela Cruz Chuh J, Roth L, Cook R, et al.
Bioconjug Chem
. 2013 Apr;
24(5):772-9.
PMID: 23578050
Antibody-drug conjugates (ADCs) are target-specific anticancer agents consisting of cytotoxic drugs covalently linked to a monoclonal antibody. The number of ADCs in the clinic is growing, and therefore thorough characterization...
12.
Montagut C, Dalmases A, Bellosillo B, Crespo M, Pairet S, Iglesias M, et al.
Nat Med
. 2012 Jan;
18(2):221-3.
PMID: 22270724
Antibodies against epidermal growth factor receptor (EGFR)--cetuximab and panitumumab--are widely used to treat colorectal cancer. Unfortunately, patients eventually develop resistance to these agents. We describe an acquired EGFR ectodomain mutation...
13.
Pastuskovas C, Mallet W, Clark S, Kenrick M, Majidy M, Schweiger M, et al.
Drug Metab Dispos
. 2010 Sep;
38(12):2309-19.
PMID: 20823292
3A5 is a novel antibody that binds repeated epitopes within CA125, an ovarian tumor antigen that is shed into the circulation. Binding to shed antigen may limit the effectiveness of...
14.
Shang Y, Mao Y, Batson J, Scales S, Phillips G, Lackner M, et al.
Mol Cancer Ther
. 2008 Sep;
7(9):2599-608.
PMID: 18790743
The insulin-like growth factor (IGF) system consists of two ligands (IGF-I and IGF-II), which both signal through IGF-I receptor (IGF-IR) to stimulate proliferation and inhibit apoptosis, with activity contributing to...
15.
Junutula J, Raab H, Clark S, Bhakta S, Leipold D, Weir S, et al.
Nat Biotechnol
. 2008 Jul;
26(8):925-32.
PMID: 18641636
Antibody-drug conjugates enhance the antitumor effects of antibodies and reduce adverse systemic effects of potent cytotoxic drugs. However, conventional drug conjugation strategies yield heterogenous conjugates with relatively narrow therapeutic index...
16.
Fu L, John L, Adams S, Yu X, Tomlinson E, Renz M, et al.
Endocrinology
. 2004 Feb;
145(6):2594-603.
PMID: 14976145
Hormonal control of metabolic rate can be important in regulating the imbalance between energy intake and expenditure that underlies the development of obesity. In mice fed a high-fat diet, human...
17.
Tsai S, Wong A, Mai E, Chan P, Mausisa G, Vasser M, et al.
Nucleic Acids Res
. 2003 Mar;
31(6):e25.
PMID: 12626724
Technologies allowing direct detection of specific RNA/DNA sequences occasionally serve as an alternative to amplification methods for gene expression studies. In these direct methods the hybridization of probes takes place...
18.
Nicholes K, Guillet S, Tomlinson E, Hillan K, Wright B, Frantz G, et al.
Am J Pathol
. 2002 Jun;
160(6):2295-307.
PMID: 12057932
Most mouse models of hepatocellular carcinoma have expressed growth factors and oncogenes under the control of a liver-specific promoter. In contrast, we describe here the formation of liver tumors in...