Si Min Zhang
Overview
Explore the profile of Si Min Zhang including associated specialties, affiliations and a list of published articles.
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15
Citations
139
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Recent Articles
1.
Valerie N, Sanjiv K, Mortusewicz O, Zhang S, Alam S, Pires M, et al.
Nat Commun
. 2024 Dec;
15(1):10347.
PMID: 39643609
Cellular target engagement technologies enable quantification of intracellular drug binding; however, simultaneous assessment of drug-associated phenotypes has proven challenging. Here, we present cellular target engagement by accumulation of mutant as...
2.
Dirks C, Bwanika H, Jemth A, Zhang S, Rudd S
Nucleosides Nucleotides Nucleic Acids
. 2024 Jun;
43(8):831-836.
PMID: 38830230
Sterile alpha motif and histidine-aspartic acid domain containing protein-1 (SAMHD1) is a deoxynucleoside triphosphate (dNTP) hydrolase that controls dNTP pools and detoxifies cancer cells of chemotherapy metabolites. TH6342 is a...
3.
Zhang S, Paulin C, Shu H, Yague-Capilla M, Michel M, Marttila P, et al.
iScience
. 2024 Feb;
27(2):108907.
PMID: 38318365
SAMHD1 is a dNTP triphosphohydrolase governing nucleotide pool homeostasis and can detoxify chemotherapy metabolites controlling their clinical responses. To understand SAMHD1 biology and investigate the potential of targeting SAMHD1 as...
4.
Ceder S, Eriksson S, Liang Y, Cheteh E, Zhang S, Fujihara K, et al.
Cell Death Dis
. 2022 Aug;
13(8):672.
PMID: 35922423
No abstract available.
5.
Bonagas N, Gustafsson N, Henriksson M, Marttila P, Gustafsson R, Wiita E, et al.
Nat Cancer
. 2022 Mar;
3(2):156-172.
PMID: 35228749
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical development. In...
6.
Ceder S, Eriksson S, Liang Y, Cheteh E, Zhang S, Fujihara K, et al.
Cell Death Dis
. 2021 Jul;
12(7):709.
PMID: 34267184
Asparaginase depletes extracellular asparagine in the blood and is an important treatment for acute lymphoblastic leukemia (ALL) due to asparagine auxotrophy of ALL blasts. Unfortunately, resistance occurs and has been...
7.
Zhang S, Rehling D, Jemth A, Throup A, Landazuri N, Almlof I, et al.
Cell Chem Biol
. 2021 Jun;
28(12):1693-1702.e6.
PMID: 34192523
Ganciclovir (GCV) is the first-line therapy against human cytomegalovirus (HCMV), a widespread infection that is particularly dangerous for immunodeficient individuals. Closely resembling deoxyguanosine triphosphate, the tri-phosphorylated metabolite of GCV (GCV-TP)...
8.
Zhang S, Wang Y, Zhang S
J Dig Dis
. 2021 Apr;
22(6):318-328.
PMID: 33871932
Objective: To investigate systematically previous studies on the accuracy of artificial intelligence (AI)-assisted diagnostic models in detecting esophageal neoplasms on endoscopic images so as to provide scientific evidence for the...
9.
Rehling D, Zhang S, Jemth A, Koolmeister T, Throup A, Wallner O, et al.
J Biol Chem
. 2021 Mar;
296:100568.
PMID: 33753169
The enzyme NUDT15 efficiently hydrolyzes the active metabolites of thiopurine drugs, which are routinely used for treating cancer and inflammatory diseases. Loss-of-function variants in NUDT15 are strongly associated with thiopurine...
10.
Makela P, Zhang S, Rudd S
BMC Res Notes
. 2021 Jan;
14(1):27.
PMID: 33468238
Objective: Combinations of pharmacological agents are essential for disease control and prevention, offering many advantages over monotherapies, with one of these being drug synergy. The state-of-the-art method to profile drug...