Tobias Koolmeister
Overview
Explore the profile of Tobias Koolmeister including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
671
Followers
0
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Recent Articles
1.
Scaletti E, Unterlass J, Almlof I, Koolmeister T, Vallin K, Kapsitidou D, et al.
FEBS J
. 2024 Jun;
291(19):4301-4322.
PMID: 38944687
Isoprene pyrophosphates play a crucial role in the synthesis of a diverse array of essential nonsterol and sterol biomolecules and serve as substrates for posttranslational isoprenylation of proteins, enabling specific...
2.
Zhang S, Paulin C, Shu H, Yague-Capilla M, Michel M, Marttila P, et al.
iScience
. 2024 Feb;
27(2):108907.
PMID: 38318365
SAMHD1 is a dNTP triphosphohydrolase governing nucleotide pool homeostasis and can detoxify chemotherapy metabolites controlling their clinical responses. To understand SAMHD1 biology and investigate the potential of targeting SAMHD1 as...
3.
Wallner O, Cazares-Korner A, Scaletti E, Masuyer G, Bekkhus T, Visnes T, et al.
ChemMedChem
. 2022 Sep;
18(1):e202200310.
PMID: 36128847
8-oxo Guanine DNA Glycosylase 1 is the initiating enzyme within base excision repair and removes oxidized guanines from damaged DNA. Since unrepaired 8-oxoG could lead to G : C→T : ...
4.
Michel M, Benitez-Buelga C, Calvo P, Hanna B, Mortusewicz O, Masuyer G, et al.
Science
. 2022 Jun;
376(6600):1471-1476.
PMID: 35737787
Oxidative DNA damage is recognized by 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), which excises 8-oxoG, leaving a substrate for apurinic endonuclease 1 (APE1) and initiating repair. Here, we describe a...
5.
Bonagas N, Gustafsson N, Henriksson M, Marttila P, Gustafsson R, Wiita E, et al.
Nat Cancer
. 2022 Mar;
3(2):156-172.
PMID: 35228749
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical development. In...
6.
Sanjiv K, Calderon-Montano J, Pham T, Erkers T, Tsuber V, Almlof I, et al.
Cancer Res
. 2021 Oct;
81(22):5733-5744.
PMID: 34593524
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy, exhibiting high levels of reactive oxygen species (ROS). ROS levels have been suggested to drive leukemogenesis and is thus a potential...
7.
Rehling D, Zhang S, Jemth A, Koolmeister T, Throup A, Wallner O, et al.
J Biol Chem
. 2021 Mar;
296:100568.
PMID: 33753169
The enzyme NUDT15 efficiently hydrolyzes the active metabolites of thiopurine drugs, which are routinely used for treating cancer and inflammatory diseases. Loss-of-function variants in NUDT15 are strongly associated with thiopurine...
8.
Tampere M, Pettke A, Salata C, Wallner O, Koolmeister T, Cazares-Korner A, et al.
Viruses
. 2020 Dec;
12(12).
PMID: 33322045
Recent RNA virus outbreaks such as Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Ebola virus (EBOV) have caused worldwide health emergencies highlighting the urgent need for new antiviral strategies....
9.
Visnes T, Benitez-Buelga C, Cazares-Korner A, Sanjiv K, Hanna B, Mortusewicz O, et al.
Nucleic Acids Res
. 2020 Nov;
48(21):12234-12251.
PMID: 33211885
Altered oncogene expression in cancer cells causes loss of redox homeostasis resulting in oxidative DNA damage, e.g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER). PARP1 coordinates BER and relies...
10.
Zhang S, Desroses M, Hagenkort A, Valerie N, Rehling D, Carter M, et al.
Nat Chem Biol
. 2020 Jul;
16(10):1120-1128.
PMID: 32690945
The NUDIX hydrolase NUDT15 was originally implicated in sanitizing oxidized nucleotides, but was later shown to hydrolyze the active thiopurine metabolites, 6-thio-(d)GTP, thereby dictating the clinical response of this standard-of-care...