Si-Lin Koo
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Explore the profile of Si-Lin Koo including associated specialties, affiliations and a list of published articles.
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19
Citations
1516
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Recent Articles
1.
Zhu G, Rahman C, Getty V, Odinokov D, Baruah P, Carrie H, et al.
Nat Biomed Eng
. 2025 Mar;
PMID: 40055581
The quantification of circulating tumour DNA (ctDNA) in blood enables non-invasive surveillance of cancer progression. Here we show that a deep-learning model can accurately quantify ctDNA from the density distribution...
2.
Chong C, Koh F, Tan H, Sivarajah S, Ng J, Ho L, et al.
Ann Coloproctol
. 2024 Oct;
40(5):451-458.
PMID: 39477330
Purpose: Total neoadjuvant therapy (TNT) is becoming the standard of care for locally advanced rectal cancer. However, surgery is deferred for months after completion, which may lead to fibrosis and...
3.
Han S, Chok A, Peh D, Ho J, Tan E, Koo S, et al.
Front Genet
. 2022 Dec;
13:933475.
PMID: 36531239
Microsatellite-instability-high (MSI-H) cancers form a spectrum of solid organ tumors collectively known as Lynch Syndrome cancers, occurring not only in a subset of colorectal, endometrial, small bowel, gastric, pancreatic, and...
4.
Li S, Zhuang S, Heit A, Koo S, Tan A, Chow I, et al.
Oncoimmunology
. 2022 Dec;
11(1):2012961.
PMID: 36524209
Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8 tumor-infiltrating lymphocytes (TILs). Here, we study CD4 TILs in human lung and...
5.
Joanito I, Wirapati P, Zhao N, Nawaz Z, Yeo G, Lee F, et al.
Nat Genet
. 2022 Jun;
54(7):963-975.
PMID: 35773407
The consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed 373,058 single-cell transcriptomes from 63 patients, focusing...
6.
Zhu G, Guo Y, Ho D, Poon P, Poh Z, Wong P, et al.
Nat Commun
. 2021 Apr;
12(1):2229.
PMID: 33850132
Profiling of circulating tumor DNA (ctDNA) may offer a non-invasive approach to monitor disease progression. Here, we develop a quantitative method, exploiting local tissue-specific cell-free DNA (cfDNA) degradation patterns, that...
7.
Lam J, Hong M, Koo S, Chua C, Lim K, Wee F, et al.
Cancer Immunol Immunother
. 2021 Feb;
70(8):2353-2365.
PMID: 33527196
Regulatory T cells (Tregs) are often enriched in tumors, where their immunosuppressive function has a key role in tumor persistence and progression. In colorectal cancer (CRC), however, Tregs are frequently...
8.
Li S, Simoni Y, Becht E, Loh C, Li N, Lachance D, et al.
Cell Rep Med
. 2020 Nov;
1(3):100039.
PMID: 33205061
Growing evidence indicates a role for the gut microbiota in modulating anti-tumor treatment efficacy in human cancer. Here we study mucosa-associated invariant T (MAIT) cells to look for evidence of...
9.
Ragulan C, Eason K, Fontana E, Nyamundanda G, Tarazona N, Patil Y, et al.
Sci Rep
. 2019 May;
9(1):7665.
PMID: 31113981
Previously, we classified colorectal cancers (CRCs) into five CRCAssigner (CRCA) subtypes with different prognoses and potential treatment responses, later consolidated into four consensus molecular subtypes (CMS). Here we demonstrate the...
10.
Tan C, Lim S, Toh Y, Ng T, Yeo A, Shwe M, et al.
Mol Neurobiol
. 2018 Nov;
56(7):4741-4750.
PMID: 30382534
Cancer-related cognitive impairment (CRCI) adversely affects cancer patients. We had previously demonstrated that the BDNF Val66Met genetic polymorphism is associated with lower odds of subjective CRCI in the multitasking and...