Shyam S Krishnakumar
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Explore the profile of Shyam S Krishnakumar including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Bose D, Bera M, Norman C, Timofeeva Y, Volynski K, Krishnakumar S
Nat Commun
. 2024 Dec;
15(1):10741.
PMID: 39738049
Neurotransmitters are released from synaptic vesicles with remarkable precision in response to presynaptic calcium influx but exhibit significant heterogeneity in exocytosis timing and efficacy based on the recent history of...
2.
Bose D, Bera M, Norman C, Timofeeva Y, Volynski K, Krishnakumar S
bioRxiv
. 2024 Apr;
PMID: 38659918
Neurotransmitters are released from synaptic vesicles with remarkable precision in response to presynaptic Ca influx but exhibit significant heterogeneity in exocytosis timing and efficacy based on the recent history of...
3.
Norman C, Krishnakumar S, Timofeeva Y, Volynski K
Commun Biol
. 2023 Oct;
6(1):1091.
PMID: 37891212
Calcium-evoked release of neurotransmitters from synaptic vesicles (SVs) is catalysed by SNARE proteins. The predominant view is that, at rest, complete assembly of SNARE complexes is inhibited ('clamped') by synaptotagmin...
4.
Kalyana Sundaram R, Chatterjee A, Bera M, Grushin K, Panda A, Li F, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(34):e2309516120.
PMID: 37590407
Here, we introduce the full functional reconstitution of genetically validated core protein machinery (SNAREs, Munc13, Munc18, Synaptotagmin, and Complexin) for synaptic vesicle priming and release in a geometry that enables...
5.
Kalyana Sundaram R, Chatterjee A, Bera M, Grushin K, Panda A, Li F, et al.
bioRxiv
. 2023 Jun;
PMID: 37333317
Significance Statement: Munc13 and Munc18 are SNARE-associated chaperones that act as "priming" factors, facilitating the formation of a pool of docked, release-ready vesicles and regulating Ca -evoked neurotransmitter release. Although...
6.
Norman C, Krishnakumar S, Timofeeva Y, Volynski K
Res Sq
. 2023 May;
PMID: 37163032
Calcium-evoked release of neurotransmitters from synaptic vesicles (SVs) is catalysed by SNARE proteins. The predominant view is that, at rest, complete assembly of SNARE complexes is inhibited ('clamped') by synaptotagmin...
7.
Sundaram R, Bera M, Coleman J, Weerakkody J, Krishnakumar S, Ramakrishnan S
Small
. 2022 Nov;
18(51):e2205567.
PMID: 36328714
Cellular plasma membranes, in their role as gatekeepers to the external environment, host numerous protein assemblies and lipid domains that manage the movement of molecules into and out of cells,...
8.
Zhu J, McDargh Z, Li F, Krishnakumar S, Rothman J, OShaughnessy B
Proc Natl Acad Sci U S A
. 2022 Sep;
119(38):e2208337119.
PMID: 36103579
Synchronous release at neuronal synapses is accomplished by a machinery that senses calcium influx and fuses the synaptic vesicle and plasma membranes to release neurotransmitters. Previous studies suggested the calcium...
9.
Bera M, Ramakrishnan S, Coleman J, Krishnakumar S, Rothman J
Elife
. 2022 Apr;
11.
PMID: 35442188
Previously we reported that Synaptotagmin-1 and Complexin synergistically clamp the SNARE assembly process to generate and maintain a pool of docked vesicles that fuse rapidly and synchronously upon Ca influx...
10.
Li F, Sundaram R, Gatta A, Coleman J, Ramakrishnan S, Krishnakumar S, et al.
FEBS Lett
. 2021 Jul;
595(17):2185-2196.
PMID: 34227103
Munc13-1 is a large banana-shaped soluble protein that is involved in the regulation of synaptic vesicle docking and fusion. Recent studies suggest that multiple copies of Munc13-1 form nano-assemblies in...