James E Rothman
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Explore the profile of James E Rothman including associated specialties, affiliations and a list of published articles.
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Articles
138
Citations
6533
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Recent Articles
1.
Li F, Coleman J, Redondo-Morata L, Kalyana Sundaram R, Stroeva E, Rothman J, et al.
Commun Biol
. 2024 Dec;
7(1):1608.
PMID: 39627539
Synaptotagmin-1 (Syt-1) self-assembles into ring-like oligomers, and genetic and biochemical evidence suggest that oligomerization is needed to clamp synaptic vesicles and stabilize them for Ca-evoked release. However, oligomerization has not...
2.
Brown C, Ghosh S, McAllister R, Kumar M, Walker G, Sun E, et al.
Nat Methods
. 2024 Nov;
22(2):412-421.
PMID: 39609567
The native membrane environment profoundly influences every aspect of membrane protein (MP) biology. Despite this, the most prevalent method of studying MPs uses detergents to disrupt and remove this vital...
3.
Schueder F, Rivera-Molina F, Su M, Marin Z, Kidd P, Rothman J, et al.
Cell
. 2024 Mar;
187(7):1769-1784.e18.
PMID: 38552613
Mapping the intricate spatial relationships between the many different molecules inside a cell is essential to understanding cellular functions in all their complexity. Super-resolution fluorescence microscopy offers the required spatial...
4.
Chelban V, Aksnes H, Maroofian R, LaMonica L, Seabra L, Siggervag A, et al.
Nat Commun
. 2024 Mar;
15(1):2269.
PMID: 38480682
Primary familial brain calcification (PFBC) is characterized by calcium deposition in the brain, causing progressive movement disorders, psychiatric symptoms, and cognitive decline. PFBC is a heterogeneous disorder currently linked to...
5.
Brown C, Ghosh S, McAllister R, Kumar M, Walker G, Sun E, et al.
bioRxiv
. 2024 Feb;
PMID: 38405833
The intricate molecular environment of the native membrane profoundly influences every aspect of membrane protein (MP) biology. Despite this, the most prevalent method of studying MPs uses detergent-like molecules that...
6.
Bera M, Radhakrishnan A, Coleman J, K Sundaram R, Ramakrishnan S, Pincet F, et al.
Proc Natl Acad Sci U S A
. 2023 Oct;
120(45):e2311484120.
PMID: 37903271
The synaptic vesicle protein Synaptophysin (Syp) has long been known to form a complex with the Vesicle associated soluble N-ethylmaleimide sensitive fusion protein attachment receptor (v-SNARE) Vesicle associated membrane protein...
7.
Li F, Grushin K, Coleman J, Pincet F, Rothman J
Proc Natl Acad Sci U S A
. 2023 Oct;
120(44):e2306086120.
PMID: 37883433
Munc13-1 is essential for vesicle docking and fusion at the active zone of synapses. Here, we report that Munc13-1 self-assembles into molecular clusters within diacylglycerol-rich microdomains present in phospholipid bilayers....
8.
Rothman J
Proc Natl Acad Sci U S A
. 2023 Sep;
120(39):e2311128120.
PMID: 37732752
This year's Lasker Basic Science Award recognizes the invention of AlphaFold, a revolutionary advance in the history of protein research which for the first time offers the practical ability to...
9.
Rothman J, Grushin K, Bera M, Pincet F
FEBS Lett
. 2023 Aug;
597(18):2233-2249.
PMID: 37643878
Evidence from biochemistry, genetics, and electron microscopy strongly supports the idea that a ring of Synaptotagmin is central to the clamping and release of synaptic vesicles (SVs) for synchronous neurotransmission....
10.
Kalyana Sundaram R, Chatterjee A, Bera M, Grushin K, Panda A, Li F, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(34):e2309516120.
PMID: 37590407
Here, we introduce the full functional reconstitution of genetically validated core protein machinery (SNAREs, Munc13, Munc18, Synaptotagmin, and Complexin) for synaptic vesicle priming and release in a geometry that enables...