Shujia Zhu
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Explore the profile of Shujia Zhu including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
677
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Recent Articles
1.
Zhang J, Duan J, Li W, Wang X, Ren S, Ye L, et al.
Sci Adv
. 2025 Mar;
11(10):eadq0444.
PMID: 40043126
-methyl-d-aspartate receptors (NMDARs), key excitatory ion channels, have gained attention as anti-depression targets. NMDARs consist of two GluN1 and two GluN2 subunits (2A-2D), which determine their pharmacological properties. Few compounds...
2.
Huang X, Sun X, Wang Q, Zhang J, Wen H, Chen W, et al.
Neuron
. 2025 Feb;
PMID: 40010346
Magnesium (Mg) is a key regulatory ion of N-methyl-ᴅ-aspartate (NMDA) receptors, including conferring them to function as coincidence detectors for excitatory synaptic transmission. However, the structural basis underlying the Mg...
3.
Zhang M, Feng J, Xie C, Song N, Jin C, Wang J, et al.
Cell
. 2025 Jan;
188(5):1198-1207.e13.
PMID: 39855198
The cerebral cortex and hippocampus are crucial brain regions for learning and memory, which depend on activity-induced synaptic plasticity involving N-methyl-ᴅ-aspartate receptors (NMDARs). However, subunit assembly and molecular architecture of...
4.
Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, et al.
Nat Struct Mol Biol
. 2024 Oct;
31(11):1809.
PMID: 39455739
No abstract available.
5.
Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, et al.
Nat Struct Mol Biol
. 2024 Sep;
31(12):1987-1996.
PMID: 39227720
Antibodies against N-methyl-D-aspartate receptors (NMDARs) are most frequently detected in persons with autoimmune encephalitis (AE) and used as diagnostic biomarkers. Elucidating the structural basis of monoclonal antibody (mAb) binding to...
6.
Guo F, Zhang B, Shen F, Li Q, Song Y, Li T, et al.
Br J Pharmacol
. 2024 May;
181(18):3483-3502.
PMID: 38779864
Background And Purpose: Sevoflurane, a commonly used inhaled anaesthetic known for its favourable safety profile and rapid onset and offset, has not been thoroughly investigated as a potential treatment for...
7.
Huang X, Chen W, Zhu S
Methods Mol Biol
. 2024 May;
2799:13-27.
PMID: 38727900
N-methyl-D-aspartate (NMDA) receptors are critical for brain function and serve as drug targets for the treatment of neurological and psychiatric disorders. They typically form the tetrameric assembly of GluN1-GluN2 (2A...
8.
Jia Y, Jia G, Guo L, Song N, Wang Y, Jiang L, et al.
Sci Bull (Beijing)
. 2023 Nov;
69(2):167-172.
PMID: 37973466
No abstract available.
9.
Wu E, Zhang J, Zhang J, Zhu S
Curr Opin Neurobiol
. 2023 Nov;
83:102806.
PMID: 37950957
N-methyl-d-aspartate receptors (NMDARs) belong to the ionotropic glutamate receptors (iGluRs) superfamily and act as coincidence detectors that are crucial to neuronal development and synaptic plasticity. They typically assemble as heterotetramers...
10.
Zhang J, Zhang M, Wang Q, Wen H, Liu Z, Wang F, et al.
Nat Struct Mol Biol
. 2023 Mar;
30(5):629-639.
PMID: 36959261
N-methyl-D-aspartate (NMDA) receptors are heterotetramers comprising two GluN1 and two alternate GluN2 (N2A-N2D) subunits. Here we report full-length cryo-EM structures of the human N1-N2D di-heterotetramer (di-receptor), rat N1-N2C di-receptor and...