Shiyun Xiao
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Explore the profile of Shiyun Xiao including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
444
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Recent Articles
1.
Xiao S, Zhang W, Li J, Manley N
Front Immunol
. 2023 Oct;
14:1261081.
PMID: 37868985
Thymic epithelial cells (TECs) are essential for T cell development in the thymus, yet the mechanisms governing their differentiation are not well understood. Lin28, known for its roles in embryonic...
2.
Li J, Wachsmuth L, Xiao S, Condie B, Manley N
Development
. 2023 Mar;
150(8).
PMID: 36975725
The transcription factor FOXN1 is essential for fetal thymic epithelial cell (TEC) differentiation and proliferation. Postnatally, Foxn1 levels vary widely between TEC subsets, from low/undetectable in putative TEC progenitors to...
3.
Postoak J, Song W, Yang G, Guo X, Xiao S, Saffold C, et al.
J Exp Med
. 2022 Aug;
219(10).
PMID: 35997680
The generation of a functional, self-tolerant T cell receptor (TCR) repertoire depends on interactions between developing thymocytes and antigen-presenting thymic epithelial cells (TECs). Cortical TECs (cTECs) rely on unique antigen-processing...
4.
Li J, Gordon J, Chen E, Xiao S, Wu L, Zuniga-Pflucker J, et al.
Development
. 2020 May;
147(12).
PMID: 32467240
The cortical and medullary thymic epithelial cell (cTEC and mTEC) lineages are essential for inducing T cell lineage commitment, T cell positive selection and the establishment of self-tolerance, but the...
5.
Xiao S, Zhang W, Manley N
PLoS One
. 2018 Feb;
13(2):e0193189.
PMID: 29462202
Background: Hematopoietic stem cells (HSCs) derived from birth through adult possess differing differentiation potential for T or B cell fate in the thymus; neonatal bone marrow (BM) cells also have...
6.
Xiao S, Zhang W, Manley N
PLoS One
. 2018 Feb;
13(2):e0193188.
PMID: 29462197
The postnatal thymus is an efficient microenvironment for T cell specification and differentiation. B cells are also present in the thymus and have been recently shown to impact T cell...
7.
Wertheimer T, Velardi E, Tsai J, Cooper K, Xiao S, Kloss C, et al.
Sci Immunol
. 2018 Jan;
3(19).
PMID: 29330161
The thymus is not only extremely sensitive to damage but also has a remarkable ability to repair itself. However, the mechanisms underlying this endogenous regeneration remain poorly understood, and this...
8.
Xiao S, Shterev I, Zhang W, Young L, Shieh J, Moore M, et al.
J Immunol
. 2017 Sep;
199(8):2701-2712.
PMID: 28931604
Total body irradiation (TBI) damages hematopoietic cells in the bone marrow and thymus; however, the long-term effects of irradiation with aging remain unclear. In this study, we found that the...
9.
Seed T, Xiao S, Manley N, Nikolich-Zugich J, Pugh J, van den Brink M, et al.
Int J Radiat Biol
. 2016 Feb;
92(2):59-70.
PMID: 26857121
Purpose: An interlaboratory comparison of radiation dosimetry was conducted to determine the accuracy of doses being used experimentally for animal exposures within a large multi-institutional research project. The background and...
10.
Li J, Liu Z, Xiao S, Manley N
Nat Commun
. 2013 Dec;
4:2959.
PMID: 24343363
The thoracic thymus is the primary vertebrate organ for T-cell generation. Accessory cervical thymi have also been identified in humans and mice, and shown in mice to be independent functional...