Shiva Kumar Shanmukhappa
Overview
Explore the profile of Shiva Kumar Shanmukhappa including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
363
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Recent Articles
1.
Singh A, Sosa M, Fang J, Shanmukhappa S, Hubaud A, Fawcett C, et al.
Cell Rep
. 2019 Sep;
28(11):2767-2776.e5.
PMID: 31509740
The hormone αKlotho regulates lifespan in mice, as knockouts die early of what appears to be accelerated aging due to hyperphosphatemia and soft tissue calcification. In contrast, the overexpression of...
2.
Roy S, Rai P, Eiymo Mwa Mpollo M, Chang K, Rizvi T, Shanmukhappa S, et al.
Am J Hematol
. 2018 Apr;
93(7):E177-E181.
PMID: 29675906
No abstract available.
3.
Kumar S, Wang J, Shanmukhappa S, Gandhi C
Am J Pathol
. 2017 Apr;
187(6):1356-1367.
PMID: 28412299
Gram-negative bacterial endotoxin lipopolysaccharide (LPS) is implicated in acute and chronic liver injury; its effects are mediated predominantly via the membrane receptor Toll-like receptor 4 (TLR4). However, TLR4-independent effects of...
4.
Lages C, Simmons J, Maddox A, Jones K, Karns R, Sheridan R, et al.
Hepatology
. 2016 Sep;
65(1):174-188.
PMID: 27641439
Conclusion: These findings identify the dendritic cell-T helper 17-macrophage axis as a target for the development of strategies to block progression of intrahepatic bile duct injury in patients with BA....
5.
Bakeer N, James J, Roy S, Wansapura J, Shanmukhappa S, Lorenz J, et al.
Proc Natl Acad Sci U S A
. 2016 Aug;
113(35):E5182-91.
PMID: 27503873
Cardiopulmonary complications are the leading cause of mortality in sickle cell anemia (SCA). Elevated tricuspid regurgitant jet velocity, pulmonary hypertension, diastolic, and autonomic dysfunction have all been described, but a...
6.
Salomonis N, Dexheimer P, Omberg L, Schroll R, Bush S, Huo J, et al.
Stem Cell Reports
. 2016 Jun;
7(1):110-25.
PMID: 27293150
The rigorous characterization of distinct induced pluripotent stem cells (iPSC) derived from multiple reprogramming technologies, somatic sources, and donors is required to understand potential sources of variability and downstream potential....
7.
Eiymo Mwa Mpollo M, Brandt E, Shanmukhappa S, Arumugam P, Tiwari S, Loberg A, et al.
J Clin Invest
. 2015 Dec;
126(2):571-84.
PMID: 26690703
Airway hyperresponsiveness (AHR) affects 55%-77% of children with sickle cell disease (SCD) and occurs even in the absence of asthma. While asthma increases SCD morbidity and mortality, the mechanisms underlying...
8.
Strait R, Posgai M, Mahler A, Barasa N, Jacob C, Kohl J, et al.
Nature
. 2015 Sep;
526(7575):728.
PMID: 26416751
No abstract available.
9.
Arumugam P, Mullins E, Shanmukhappa S, Monia B, Loberg A, Shaw M, et al.
Blood
. 2015 Aug;
126(15):1844-55.
PMID: 26286849
Sickle cell disease (SCD) results in vascular occlusions, chronic hemolytic anemia, and cumulative organ damage. A conspicuous feature of SCD is chronic inflammation and coagulation system activation. Thrombin (factor IIa...
10.
Miethke A, Zhang W, Simmons J, Taylor A, Shi T, Shanmukhappa S, et al.
Hepatology
. 2015 Jul;
63(2):512-23.
PMID: 26172874
Unlabelled: Deficiency of multidrug resistance 2 (mdr2), a canalicular phospholipid floppase, leads to excretion of low-phospholipid "toxic" bile causing progressive cholestasis. We hypothesize that pharmacological inhibition of the ileal, apical...