Jose A Cancelas
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Explore the profile of Jose A Cancelas including associated specialties, affiliations and a list of published articles.
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147
Citations
3593
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Recent Articles
1.
Hsu A, Huang Q, Pi X, Fu J, Raghunathan K, Ghimire L, et al.
Cell
. 2025 Feb;
PMID: 39938514
Although subsets with immunosuppressive properties exist, neutrophils are typically known for their pro-inflammatory role and pathogen clearance capabilities. Here, we reveal that neutrophils can paradoxically aid in resolving inflammation by...
2.
Mehta P, Nelson A, Loveless S, Lane A, Fukuda T, Teusink-Cross A, et al.
Blood Adv
. 2025 Jan;
PMID: 39820512
Fanconi anemia (FA) is a rare inherited disorder characterized by progressive bone marrow failure (BMF) and a predisposition to malignancy. Systemic reactive-oxygen species (ROS) and increased sensitivity of FA hematopoietic...
3.
Nayak R, Emberesh S, Trump L, Trump L, Wellendorf A, Wellendorf A, et al.
J Clin Invest
. 2024 Nov;
135(2.
PMID: 39560992
Severe congenital neutropenia (SCN) is frequently associated with dominant point mutations in ELANE, the gene encoding neutrophil elastase (NE). Chronic administration of granulocyte colony-stimulating factor (G-CSF) is a first-line treatment...
4.
Hegde S, Akbar H, Wellendorf A, Nestheide S, Johnson J, Zhao X, et al.
Blood
. 2024 Aug;
144(16):1732-1746.
PMID: 39088777
Patients with thrombocytopenia require platelet transfusion to prevent and stop hemorrhage. Cold storage of platelets results in complex molecular lesions, including changes in membrane microdomains that are recognized by host...
5.
Prasad P, Cancelas J
Cells
. 2024 Jun;
13(11.
PMID: 38891042
The bone marrow (BM) stromal cell microenvironment contains non-hematopoietic stromal cells called mesenchymal stromal cells (MSCs). MSCs are plastic adherent, form CFU-Fs, and give rise to osteogenic, adipogenic, chondrogenic progenitors,...
6.
Khoury R, Grimley M, Nelson A, Leemhuis T, Cancelas J, Cook E, et al.
Am J Transplant
. 2024 Apr;
24(9):1634-1643.
PMID: 38643944
Reactivation or primary infection with double-stranded DNA viruses is common in recipients of solid organ transplants (SOTs) and is associated with significant morbidity and mortality. Treatment with conventional antiviral medications...
7.
Arumugam P, Carey B, Wikenheiser-Brokamp K, Krischer J, Wessendarp M, Shima K, et al.
Mol Ther Methods Clin Dev
. 2024 Apr;
32(2):101213.
PMID: 38596536
Pulmonary macrophage transplantation (PMT) is a gene and cell transplantation approach in development as therapy for hereditary pulmonary alveolar proteinosis (hPAP), a surfactant accumulation disorder caused by mutations in (and...
8.
Singh A, Prasad P, Cancelas J
Front Cell Dev Biol
. 2024 Jan;
11:1325291.
PMID: 38169927
Hematopoietic stem cell (HSC) transplantation-based treatments are in different phases of clinical development, ranging from current therapies to a promise in the repair and regeneration of diseased tissues and organs....
9.
Vandenbroeke T, Gloor C, Wingfield T, Leite C, Carr K, Turner C, et al.
Transfusion
. 2023 Nov;
64(1):132-140.
PMID: 37991217
Background: Increasing the number of collections of whole blood-derived platelets (WBDP) and lengthening the allowable storage time may alleviate platelet (PLT) shortages. There is a need for new PLT pooling...
10.
Solomon M, Song B, Govindarajah V, Good S, Arasu A, Hinton E, et al.
J Exp Med
. 2023 Nov;
221(1).
PMID: 37910046
The dynamics of the hematopoietic flux responsible for blood cell production in native conditions remains a matter of debate. Using CITE-seq analyses, we uncovered a distinct progenitor population that displays...