Shirley M-H Sy
Overview
Explore the profile of Shirley M-H Sy including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
521
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0
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Recent Articles
1.
Shao Z, Li F, Sy S, Yan W, Zhang Z, Gong D, et al.
J Struct Biol
. 2011 Dec;
177(2):459-68.
PMID: 22154951
MCPH1 is especially important for linking chromatin remodeling to DNA damage response. It contains three BRCT (BRCA1-carboxyl terminal) domains. The N-terminal region directly binds with chromatin remodeling complex SWI-SNF, and...
2.
Lok G, Sy S, Dong S, Ching Y, Tsao S, Thomson T, et al.
Nucleic Acids Res
. 2011 Sep;
40(1):196-205.
PMID: 21911360
Pairing of a given E3 ubiquitin ligase with different E2s allows synthesis of ubiquitin conjugates of different topologies. While this phenomenon contributes to functional diversity, it remains largely unknown how...
3.
Sy S, Jiang J, Dong S, Lok G, Wu J, Cai H, et al.
J Biol Chem
. 2011 May;
286(25):22355-61.
PMID: 21558560
Histone ubiquitylation is emerging as an important protective component in cellular responses to DNA damage. The ubiquitin ligases RNF8 and RNF168 assemble ubiquitin chains onto histone molecules surrounding DNA breaks...
4.
Dray E, Etchin J, Wiese C, Saro D, Williams G, Hammel M, et al.
Nat Struct Mol Biol
. 2010 Sep;
17(10):1255-9.
PMID: 20871616
Homologous recombination mediated by RAD51 recombinase helps eliminate chromosomal lesions, such as DNA double-strand breaks induced by radiation or arising from injured DNA replication forks. The tumor suppressors BRCA2 and...
5.
Huen M, Huang J, Leung J, Sy S, Leung K, Ching Y, et al.
Mol Cell
. 2010 Mar;
37(6):854-64.
PMID: 20347427
Dynamic changes of chromatin structure facilitate diverse biological events, including DNA replication, repair, recombination, and gene transcription. Recent evidence revealed that DNA damage elicits alterations to the chromatin to facilitate...
6.
Sy S, Huen M, Chen J
J Biol Chem
. 2009 Jun;
284(32):21127-31.
PMID: 19553677
PALB2 is an integral component of the BRCA complex important for recombinational DNA repair. However, exactly how this activity is regulated in vivo remains unexplored. Here we provide evidence to...
7.
Sy S, Huen M, Zhu Y, Chen J
J Biol Chem
. 2009 May;
284(27):18302-10.
PMID: 19423707
Maintenance of genomic stability ensures faithful transmission of genetic information and helps suppress neoplastic transformation and tumorigenesis. Although recent progress has advanced our understanding of DNA damage checkpoint regulations, little...
8.
Maddika S, Sy S, Chen J
J Biol Chem
. 2009 Mar;
284(19):12998-3003.
PMID: 19321445
Proper activation of checkpoint during mitotic stress is an important mechanism to prevent genomic instability. Chfr (Check point protein with FHA (Forkhead-associated domain) and RING domains) is a ubiquitin-protein isopeptide...
9.
Huen M, Sy S, van Deursen J, Chen J
J Biol Chem
. 2008 Mar;
283(17):11073-7.
PMID: 18319261
Chromatin endowed by histone modifications governs chromatin structure, which in turn represents a means to regulate cellular processes, including transcription and heterochromatin formation. Recent evidence revealed a plethora of enzymes...
10.
Pang E, Bai A, To K, Sy S, Wong N, Lai P, et al.
Hepatology
. 2007 Jun;
46(2):436-45.
PMID: 17559150
Unlabelled: Metastasis is a major cause of cancer morbidity and mortality in individuals with hepatocellular carcinoma (HCC), yet little is known about the underlying molecular basis. Using genetic information derived...