Shin-ichi Akiyama
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Explore the profile of Shin-ichi Akiyama including associated specialties, affiliations and a list of published articles.
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91
Citations
1235
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Recent Articles
1.
Kamimura M, Furukawa T, Akiyama S, Nagasaki Y
Biomater Sci
. 2020 Jun;
1(4):361-367.
PMID: 32481901
A pH-sensitive nanoparticle was prepared using our original amphiphilic block copolymer, poly(ethylene glycol)-b-poly(4-vinylbenzylphosphonate) (PEG-b-PVBP), which possesses phosphate groups as a side chain of its hydrophobic segment (termed here, phosphate nanoparticle...
2.
Nishizawa Y, Ikeda R, Yamamoto M, Kawahara K, Shinsato Y, Minami K, et al.
Anticancer Res
. 2019 Aug;
39(8):4129-4136.
PMID: 31366497
Background/aim: 5-Aza-2-deoxycytidine (5-Aza-CdR) enhances the sensitivity to 5-fluorouracil (5-FU), but the molecular mechanism is not fully understood. The aim of this study was to investigate the molecular mechanism that enhances...
3.
Asano M, Ishii T, Hirayama A, Mizuno M, Suzuki Y, Sakata F, et al.
Clin Exp Nephrol
. 2018 Jul;
23(1):122-134.
PMID: 29968125
Background: Ultrafiltration failure associated with peritoneal membrane dysfunction is one of the main complications for patients on long-term peritoneal dialysis (PD). The dialysate-to-plasma concentration ratio (D/P) of creatinine is widely...
4.
Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, et al.
Sci Rep
. 2018 May;
8(1):6760.
PMID: 29713062
Thymidine phosphorylase (TP) is a rate-limiting enzyme in the thymidine catabolic pathway. TP is identical to platelet-derived endothelial cell growth factor and contributes to tumour angiogenesis. TP induces the generation...
5.
Furukawa T, Tabata S, Yamamoto M, Kawahara K, Shinsato Y, Minami K, et al.
Pharmacol Res
. 2018 Apr;
132:15-20.
PMID: 29604437
Thymidine phosphorylase (TP) is a rate-limiting enzyme in thymidine catabolism. TP has several important roles in biological and pharmacological mechanisms; importantly TP acts as an angiogenic factor and one of...
6.
Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, et al.
Cell Rep
. 2017 May;
19(7):1313-1321.
PMID: 28514652
Thymidine phosphorylase (TP), a rate-limiting enzyme in thymidine catabolism, plays a pivotal role in tumor progression; however, the mechanisms underlying this role are not fully understood. Here, we found that...
7.
Nguyen V, Fuse Y, Tamaoki J, Akiyama S, Muratani M, Tamaru Y, et al.
Oxid Med Cell Longev
. 2017 Jan;
2016:5720574.
PMID: 28116036
The Keap1-Nrf2 system is an evolutionarily conserved defense mechanism against oxidative and xenobiotic stress. Besides the exogenous stress response, Nrf2 has been found to regulate numerous cellular functions, including protein...
8.
Minami K, Shinsato Y, Yamamoto M, Takahashi H, Zhang S, Nishizawa Y, et al.
J Pharmacol Sci
. 2015 Apr;
127(3):319-25.
PMID: 25837929
Gemcitabine is widely used for pancreatic, lung, and bladder cancer. However, drug resistance against gemcitabine is a large obstacle to effective chemotherapy. Nucleoside transporters, nucleoside and nucleotide metabolic enzymes, and...
9.
Tabata S, Ikeda R, Yamamoto M, Shimaoka S, Mukaida N, Takeda Y, et al.
Oncotarget
. 2014 Oct;
5(21):10473-85.
PMID: 25350954
Thymidine phosphorylase (TP) promotes angiogenesis and metastasis, and confers resistance to anticancer agents in some cancer cell types. We previously reported that TP stimulates the expression of interleukin (IL)-8 in...
10.
Minami K, Kamijo Y, Nishizawa Y, Tabata S, Horikuchi F, Yamamoto M, et al.
Anticancer Res
. 2014 Sep;
34(9):4767-73.
PMID: 25202056
A previously established arsenite-resistant cell line, KAS, is also resistant to a variety of anticancer drugs. In order to understand responsible molecules for the multidrug resistance phenotype of KAS cells,...