Shiho Yamamoto
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Explore the profile of Shiho Yamamoto including associated specialties, affiliations and a list of published articles.
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22
Citations
290
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Recent Articles
1.
Yoshida S, Uehara S, Kondo N, Takahashi Y, Yamamoto S, Kameda A, et al.
J Med Chem
. 2022 Jul;
65(15):10655-10673.
PMID: 35904556
Recent technological innovations have led to the development of methods for the rapid identification of high-affinity macrocyclic peptides for a wide range of targets; however, it is still challenging to...
2.
Unoh Y, Uehara S, Nakahara K, Nobori H, Yamatsu Y, Yamamoto S, et al.
J Med Chem
. 2022 Mar;
65(9):6499-6512.
PMID: 35352927
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths and threatens public health and safety. Despite the rapid...
3.
Ueno T, Matsuoka E, Asada N, Yamamoto S, Kanegawa N, Ito M, et al.
J Med Chem
. 2021 Sep;
64(19):14165-14174.
PMID: 34553947
β-Site amyloid precursor protein-cleaving enzyme 1 (BACE1) is considered to be a promising target for treating Alzheimer's disease. However, all clinical BACE1 inhibitors have failed due to lack of efficacy,...
4.
Kobayashi K, Nagase H, Sugimoto N, Yamamoto S, Tanaka A, Fukunaga K, et al.
Asia Pac Allergy
. 2021 Aug;
11(3):e31.
PMID: 34386407
Background: Mepolizumab, a humanized antibody targeting interleukin-5, decreases the number of blood eosinophils and the frequency of exacerbation of severe asthma. Galectin-10 is a protein within the cytoplasm of eosinophils...
5.
Hayashi K, Uehara S, Yamamoto S, Cary D, Nishikawa J, Ueda T, et al.
ACS Med Chem Lett
. 2021 Jul;
12(7):1093-1101.
PMID: 34267879
Nicotinamide -methyltransferase (NNMT), which catalyzes the methylation of nicotinamide, is a cytosolic enzyme that has attracted much attention as a therapeutic target for a variety of diseases. However, despite the...
6.
Nakahara K, Mitsuoka Y, Kasuya S, Yamamoto T, Yamamoto S, Ito H, et al.
Eur J Med Chem
. 2021 Mar;
216:113270.
PMID: 33765486
β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) has been pursued as a prime target for the treatment of Alzheimer's disease (AD). In this report, we describe the discovery of...
7.
Fujimoto K, Yoshida S, Tadano G, Asada N, Fuchino K, Suzuki S, et al.
J Med Chem
. 2021 Mar;
64(6):3075-3085.
PMID: 33719429
BACE1 is an attractive target for disease-modifying treatment of Alzheimer's disease. BACE2, having high homology around the catalytic site, poses a critical challenge to identifying selective BACE1 inhibitors. Recent evidence...
8.
Koriyama Y, Hori A, Ito H, Yonezawa S, Baba Y, Tanimoto N, et al.
J Med Chem
. 2021 Feb;
64(4):1873-1888.
PMID: 33588527
Accumulation of amyloid β peptides (Aβ) is thought to be one of the causal factors of Alzheimer's disease (AD). The aspartyl protease β-site amyloid precursor protein cleaving enzyme 1 (BACE1)...
9.
Yamamoto S, Nagamori T, Komatsu S, Shirai M, Suzutani T, Oki J
Brain Dev
. 2020 Feb;
42(4):369-372.
PMID: 32001045
We present the case of an 8-month-old boy with the repeated recurrence of vesicles from the time of birth and who subsequently manifested psychomotor developmental delay. We retrospectively diagnosed the...
10.
Oka H, Nagamori T, Yamamoto S, Manabe H, Taketazu G, Mukai T, et al.
Pediatr Int
. 2019 Aug;
61(8):777-780.
PMID: 31410918
Background: The appropriate antimicrobial treatment period for febrile urinary tract infection (UTI) can be changed, depending on whether the patient has acute focal bacterial nephritis (AFBN). The aim of this...