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Shiho Hirohara

Explore the profile of Shiho Hirohara including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 22
Citations 103
Followers 0
Related Specialties
Biochemistry
Chemistry
Biology
Top 10 Co-Authors
Makoto Obata
Masao Tanihara
Shigenobu Yano
Tsuyoshi Ando
Hiroki Alitomo
Chikara Ohtsuki
Kohei Sharyo
Shin-Ichi Ogata
Kayo Terada
Kiyomi Kakiuchi
Published In
J Photochem Photobiol B
Bioorg Med Chem
J Med Chem
Bioconjug Chem
Photochem Photobiol
Affiliations
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Recent Articles
1.
Micelle-encapsulated IR783 for enhanced photothermal therapy in mouse breast cancer
Osaki T, Ueda M, Hirohara S, Obata M
Photodiagnosis Photodyn Ther . 2024 Sep; 49:104340. PMID: 39322051
Background: Photothermal therapy, an emerging cancer treatment, selectively eliminates lesions using photothermal compounds that convert light into heat. IR783, a near-infrared fluorescent heptamethine cyanine dye, has been used to achieve...
2.
RAFT Synthesis and Characterization of Poly(Butyl--2-(,-Dimethylamino)Ethyl Acrylates)--Poly(Polyethylene Glycol Monomethyl Ether Acrylate) as a Photosensitizer Carrier for Photodynamic Therapy
Obata M, Hirohara S
Materials (Basel) . 2023 Jun; 16(11). PMID: 37297326
Polymer micelles are promising drug delivery systems for highly hydrophobic photosensitizers in photodynamic therapy (PDT) applications. We previously developed pH-responsive polymer micelles consisting of poly(styrene--2-(,-dimethylamino)ethyl acrylate)--poly(polyethylene glycol monomethyl ether acrylate)...
3.
Effect of tertiary amino groups in the hydrophobic segment of an amphiphilic block copolymer on zinc phthalocyanine encapsulation and photodynamic activity
Obata M, Ishihara E, Hirohara S
RSC Adv . 2022 Jul; 12(28):18144-18153. PMID: 35800304
Polymer micelles are promising nanocarriers for hydrophobic photosensitizers of photodynamic therapy (PDT). Poly(styrene--(2-(,-dimethylamino)ethyl acrylate))--poly(polyethylene glycol monomethyl ether acrylate) (P(St--DMAEA)--PPEGA; 1) was prepared reversible addition and fragmentation chain transfer (RAFT) polymerization...
4.
Photosensitized Protein-Damaging Activity, Cytotoxicity, and Antitumor Effects of P(V)porphyrins Using Long-Wavelength Visible Light through Electron Transfer
Hirakawa K, Ouyang D, Ibuki Y, Hirohara S, Okazaki S, Kono E, et al.
Chem Res Toxicol . 2018 Apr; 31(5):371-379. PMID: 29658271
Photodynamic therapy (PDT) is a less-invasive treatment for cancer through the administration of less-toxic porphyrins and visible-light irradiation. Photosensitized damage of biomacromolecules through singlet oxygen (O) generation induces cancer cell...
5.
Synthesis, photophysical properties, and photodynamic activity of positional isomers of TFPP-glucose conjugates
Fadlan A, Tanimoto H, Ito T, Aritomi Y, Ueno M, Tokuda M, et al.
Bioorg Med Chem . 2018 Mar; 26(8):1848-1858. PMID: 29496414
The synthesis and characterization of a 'complete set' of positional isomers of tetrakis(perfluorophenyl)porphyrins (TFPP)-glucose conjugates (1OH, 2OH, 3OH, 4OH, and 6OH) are reported herein. The cellular uptake and photocytotoxicity of...
6.
Syntheses, photophysical properties, and photocytotoxicities of tetrakis(fluorophenyl)porphyrin derivatives bearing 2-hydroxyethylthio groups
Obata M, Hirohara S
J Photochem Photobiol B . 2016 Jul; 162:324-331. PMID: 27419616
Porphyrin derivatives for photodynamic therapy are frequently modified with hydrophilic groups to improve their water solubility; however, such hydrophilic groups not only improve the solubility but also affect the photodynamic...
7.
Synthesis, Photophysical Properties, and Biological Evaluation of trans-Bisthioglycosylated Tetrakis(fluorophenyl)chlorin for Photodynamic Therapy
Hirohara S, Oka C, Totani M, Obata M, Yuasa J, Ito H, et al.
J Med Chem . 2015 Oct; 58(21):8658-70. PMID: 26457363
trans-Bisthioglycosylated tetrakis(fluorophenyl)chlorin (7) was designed as a powerful photodynamic therapy (PDT) photosensitizer based on the findings of our systematic studies. We show here that the trans-bisthioglycosylated structure of 7 enhanced...
8.
Encapsulation of rat bone marrow stromal cells using a poly-ion complex gel of chitosan and succinylated poly(Pro-Hyp-Gly)
Kusumastuti Y, Shibasaki Y, Hirohara S, Kobayashi M, Terada K, Ando T, et al.
J Tissue Eng Regen Med . 2015 Jan; 11(3):869-876. PMID: 25627868
Encapsulation of stem cells into a three-dimensional (3D) scaffold is necessary to achieve tissue regeneration. Prefabricated 3D scaffolds, such as fibres or porous sponges, have limitations regarding homogeneous cell distribution....
9.
Selective accumulation of [⁶²Zn]-labeled glycoconjugated porphyrins as multi-functional positron emission tomography tracers in cancer cells
Tamura M, Matsui H, Hirohara S, Kakiuchi K, Tanihara M, Takahashi N, et al.
Bioorg Med Chem . 2014 Mar; 22(8):2563-70. PMID: 24656799
Positron-emission tomography (PET) can be used to visualize active stage cancer. Fluorine-18 ([(18)F])-labeled 2-([(18)F])2-deoxy-2-fluoroglucose (([(18)F])-FDG), which accumulates in glucose-dependent tissues, is a good cancer-targeting tracer. However, ([(18)F])-FDG is obscured in...
10.
Sugar and heavy atom effects of glycoconjugated chlorin palladium complex on photocytotoxicity
Hirohara S, Kawasaki Y, Funasako R, Yasui N, Totani M, Alitomo H, et al.
Bioconjug Chem . 2012 Sep; 23(9):1881-90. PMID: 22946640
Palladium(II) complexes of glycoconjugated porphyrin and pyrrolidine-fused chlorin were prepared to examine sugar and heavy atom effects on in vitro photocytotoxicity. Cellular uptake into HeLa cells was enhanced by introducing...