Shih-Chieh Chiang
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Explore the profile of Shih-Chieh Chiang including associated specialties, affiliations and a list of published articles.
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17
Citations
644
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Recent Articles
1.
Bell C, Pelly V, Moeini A, Chiang S, Flanagan E, Bromley C, et al.
Nat Commun
. 2022 Apr;
13(1):2063.
PMID: 35440553
Cytotoxic therapies, besides directly inducing cancer cell death, can stimulate immune-dependent tumor growth control or paradoxically accelerate tumor progression. The underlying mechanisms dictating these opposing outcomes are poorly defined. Here,...
2.
Pelly V, Moeini A, Roelofsen L, Bonavita E, Bell C, Hutton C, et al.
Cancer Discov
. 2021 May;
11(10):2602-2619.
PMID: 34031121
Identifying strategies to improve the efficacy of immune checkpoint blockade (ICB) remains a major clinical need. Here, we show that therapeutically targeting the COX2/PGE/EP2-4 pathway with widely used nonsteroidal and...
3.
Bonavita E, Bromley C, Jonsson G, Pelly V, Sahoo S, Walwyn-Brown K, et al.
Immunity
. 2020 Nov;
53(6):1215-1229.e8.
PMID: 33220234
Inflammation can support or restrain cancer progression and the response to therapy. Here, we searched for primary regulators of cancer-inhibitory inflammation through deep profiling of inflammatory tumor microenvironments (TMEs) linked...
4.
Fielden J, Wiseman K, Torrecilla I, Li S, Hume S, Chiang S, et al.
Nat Commun
. 2020 Mar;
11(1):1274.
PMID: 32152270
Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. TOP1 is also a major driver of endogenous genome instability, particularly when its catalytic intermediate-a covalent...
5.
Moradzadeh M, Ghorbani A, Erfanian S, Mohaddes S, Rahimi H, Karimiani E, et al.
J Cell Biochem
. 2018 Sep;
120(2):1943-1957.
PMID: 30203596
Crocetin, the major carotenoid in saffron, exhibits potent anticancer effects. However, the antileukemic effects of crocetin are still unclear, especially in primary acute promyelocytic leukemia (APL) cells. In the current...
6.
Kassouf N, Kay C, Volkov A, Chiang S, Birch-Machin M, El-Khamisy S, et al.
Free Radic Biol Med
. 2018 Jul;
126:153-165.
PMID: 30055236
Ultraviolet-A and melanin are implicated in melanoma, but whether melanin in vivo screens or acts as a UVA photosensitiser is debated. Here, we investigate the effect of UVA-irradiation on non-pigmented,...
7.
Liao C, Beveridge R, Hudson J, Parker J, Chiang S, Ray S, et al.
Cell Rep
. 2018 Jun;
23(11):3352-3365.
PMID: 29898404
Genomic damage can feature DNA-protein crosslinks whereby their acute accumulation is utilized to treat cancer and progressive accumulation causes neurodegeneration. This is typified by tyrosyl DNA phosphodiesterase 1 (TDP1), which...
8.
Chiang S, Liversidge K, El-Khamisy S
Methods Mol Biol
. 2017 Nov;
1703:173-181.
PMID: 29177742
Topoisomerase poisons act by inducing abortive topoisomerase reactions, which generate stable protein-DNA breaks (PDBs) that interfere with transcription elongation and progression of replication forks. In vertebrates, Tyrosyl-DNA phosphodiesterase 1 (TDP1)...
9.
Walker C, Herranz-Martin S, Karyka E, Liao C, Lewis K, Elsayed W, et al.
Nat Neurosci
. 2017 Jul;
20(9):1225-1235.
PMID: 28714954
Hexanucleotide repeat expansions represent the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, though the mechanisms by which such expansions cause neurodegeneration are poorly understood. We...
10.
Chiang S, Meagher M, Kassouf N, Hafezparast M, McKinnon P, Haywood R, et al.
Sci Adv
. 2017 May;
3(4):e1602506.
PMID: 28508041
Breakage of one strand of DNA is the most common form of DNA damage. Most damaged DNA termini require end-processing in preparation for ligation. The importance of this step is...