Shigeto Kawai
Overview
Explore the profile of Shigeto Kawai including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
328
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Recent Articles
1.
Tanaka K, Kawai S, Fujii E, Yano M, Miyayama T, Nakano K, et al.
Sci Rep
. 2023 Jul;
13(1):12130.
PMID: 37495742
The in-depth analysis of the ADME profiles of drug candidates using in vitro models is essential for drug development since a drug's exposure in humans depends on its ADME properties....
2.
Kawai S, Nakano K, Tamai K, Fujii E, Yamada M, Komoda H, et al.
Sci Rep
. 2021 Dec;
11(1):24305.
PMID: 34934075
Tumor nests in lung squamous cell carcinoma (LUSC) have a hierarchical structure resembling squamous epithelium. The nests consist of basal-like cells on the periphery and layers of keratinocyte-like cells that...
3.
Yamazaki M, Kato A, Oki E, Zaitsu Y, Kato C, Nakano K, et al.
Lab Invest
. 2020 Jul;
101(1):12-25.
PMID: 32728120
New cancer characteristics can be discovered by focusing on the process of tumor formation. Cancer stem cells (CSCs) are a key subpopulation, as they are theorized to be at the...
4.
Fujii E, Funahashi S, Taniguchi K, Kawai S, Nakano K, Kato A, et al.
J Toxicol Pathol
. 2020 May;
33(2):67-76.
PMID: 32425339
Desmoglein-3 (DSG3) is a potential target of cytotoxic antibody therapy for squamous cell carcinomas but is also expressed in various normal squamous epithelia. We obtained information about DSG3 distribution in...
5.
Kawai S, Yamazaki M, Shibuya K, Yamazaki M, Fujii E, Nakano K, et al.
Sci Rep
. 2020 Feb;
10(1):3156.
PMID: 32081957
Colorectal cancer demonstrates intra-tumour heterogeneity formed by a hierarchical structure comprised of cancer stem cells (CSCs) and their differentiated progenies. The mechanism by which CSCs are maintained and differentiated needs...
6.
Funahashi S, Kawai S, Fujii E, Taniguchi K, Nakano K, Ishikawa S, et al.
J Biochem
. 2018 Sep;
164(6):471-481.
PMID: 30239818
It is ideal for the target antigen of a cytotoxic therapeutic antibody against cancer to be cancer-specific, but such antigens are rare. Thus an alternative strategy for target selection is...
7.
Fujii E, Yamazaki M, Kawai S, Ohtani Y, Watanabe T, Kato A, et al.
J Toxicol Pathol
. 2018 Feb;
31(1):81-85.
PMID: 29479145
-cultured 3D structures called organoids have become important tools for biological research, but there is little information concerning simple and efficient methods to evaluate organoid morphology. To address this issue,...
8.
Funahashi S, Suzuki Y, Nakano K, Kawai S, Suzuki M
J Biochem
. 2016 Dec;
161(4):361-368.
PMID: 28013222
Leucine-rich repeat-containing G protein-coupled receptor 6 (LGR6) is a seven-pass transmembrane protein known to be a marker of stem cells in several organs. To deepen our understanding of the cell...
9.
Harada T, Ozaki S, Oda A, Tsuji D, Ikegame A, Iwasa M, et al.
PLoS One
. 2014 Jan;
8(12):e83905.
PMID: 24386306
The immunomodulatory drug lenalidomide (Len) has drawn attention to potentiate antibody-dependent cellular cytotoxicity (ADCC)-mediated immunotherapies. We developed the defucosylated version (YB-AHM) of humanized monoclonal antibody against HM1.24 (CD317) overexpressed in...
10.
Ishiguro T, Kawai S, Habu K, Sugimoto M, Shiraiwa H, Iijima S, et al.
Cancer Sci
. 2010 Aug;
101(10):2227-33.
PMID: 20701608
The humanized monoclonal antibody (mAb) against CD317 antigen (anti-HM1.24 antibody; AHM), which is highly expressed on multiple myeloma (MM), induces antibody-dependent cellular cytotoxicity (ADCC). However, the antitumor activity of AHM...