Shigeo Ikegawa
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Explore the profile of Shigeo Ikegawa including associated specialties, affiliations and a list of published articles.
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Articles
49
Citations
324
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Recent Articles
1.
Minowa K, Rodriguez-Agudo D, Suzuki M, Muto Y, Hirai S, Wang Y, et al.
J Lipid Res
. 2023 Mar;
64(5):100363.
PMID: 36966904
CYP7B1 catalyzes mitochondria-derived cholesterol metabolites such as (25R)26-hydroxycholesterol (26HC) and 3β-hydroxy-5-cholesten-(25R)26-oic acid (3βHCA) and facilitates their conversion to bile acids. Disruption of 26HC/3βHCA metabolism in the absence of CYP7B1 leads...
2.
Kakiyama G, Minowa K, Rodriguez-Agudo D, Martin R, Takei H, Mitamura K, et al.
Am J Physiol Gastrointest Liver Physiol
. 2022 Oct;
323(5):G488-G500.
PMID: 36193897
Oxysterol 7α-hydroxylase (CYP7B1) controls the levels of intracellular regulatory oxysterols generated by the "acidic pathway" of cholesterol metabolism. Previously, we demonstrated that an inability to upregulate CYP7B1 in the setting...
3.
Murai T, Jin S, Itoh M, Horie Y, Higashi T, Ikegawa S
Steroids
. 2020 Feb;
158:108605.
PMID: 32084504
Steryl glucosides (SGs) and acylated steryl glucosides (ASGs) are phytochemicals found in plant-based foods and are known as bioactive compounds with potential health benefits. These include anti-inflammatory properties, anti-diabetic effects,...
4.
Horie Y, Goto A, Tsubuku S, Itoh M, Ikegawa S, Ogawa S, et al.
Anal Sci
. 2018 Dec;
35(4):427-432.
PMID: 30584182
Many studies have demonstrated that the dietary supplementation of polyamines, especially spermidine (SPD), prevents age-related diseases. Rice bran is rich in polyamines and their amounts could be increased by fermentation...
5.
Matsumoto T, Yamazaki W, Jo A, Ogawa S, Mitamura K, Ikegawa S, et al.
Anal Sci
. 2018 Jun;
34(9):1003-1009.
PMID: 29887546
The determination of urinary tetrahydroglucocorticoid (THGC) glucuronides might prove helpful in the diagnosis, pathophysiological analysis and assessment of the therapeutic efficacy of the diseases caused by abnormal cortisol secretion. We...
6.
Ogawa S, Takafuji K, Tsubuku S, Horie Y, Ikegawa S, Higashi T
J Pharm Biomed Anal
. 2017 May;
142:162-170.
PMID: 28531830
Hydroxycinnamic acids (HCAs) and hydroxybenzoic acids (HBAs) are antioxidant phytochemicals found in rice and effective for the prevention of human diseases including cancer. FBRA, which is a functional food manufactured...
7.
Satoh R, Ogata H, Saito T, Zhou B, Omura K, Kurabuchi S, et al.
Lipids
. 2016 Apr;
51(6):757-68.
PMID: 27108034
Two major bile acids were isolated from the gallbladder bile of two hornbill species from the Bucerotidae family of the avian order Bucerotiformes Buceros bicornis (great hornbill) and Penelopides panini...
8.
Sato nee Okihara R, Saito T, Ogata H, Nakane N, Namegawa K, Sekiguchi S, et al.
Steroids
. 2016 Jan;
107:112-20.
PMID: 26768415
Bile alcohols and bile acids from gallbladder bile of the Arapaima gigas, a large South American freshwater fish, were isolated by reversed-phase high-performance liquid chromatography. The structures of the major...
9.
Miura Y, Hui S, Shrestha R, Hiruma T, Takeda S, Fuda H, et al.
Steroids
. 2015 Dec;
107:1-9.
PMID: 26703443
The accurate analysis of trace component in complex biological matrices requires the use of reliable standards. For liquid chromatography/mass spectrometry analysis, the stable isotope-labeled derivatives of the analyte molecules are...
10.
Mabuchi M, Shimizu T, Ueda M, Mitamura K, Ikegawa S, Tanaka A
Bioorg Med Chem Lett
. 2015 May;
25(14):2788-92.
PMID: 26025877
Solid materials for affinity resins bearing long PEG spacers between a functional group used for immobilization of a bio-active compound and the solid surface were synthesized to capture not only...