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Shiang Y Lim

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Articles 69
Citations 1993
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Recent Articles
1.
Lees J, Greening D, Rudd D, Cross J, Rosdah A, Lai X, et al.
J Mol Cell Cardiol Plus . 2025 Jan; 9():100085. PMID: 39803589
Dynamin-related protein 1 (Drp1) is a mitochondrial fission protein and a viable target for cardioprotection against myocardial ischaemia-reperfusion injury. Here, we reported a novel Drp1 inhibitor (DRP1i1), delivered using a...
2.
Kong A, Idris Z, Urrutia-Cabrera D, Lees J, Phang R, Mitchell G, et al.
Biochem Biophys Rep . 2024 Dec; 40:101876. PMID: 39634339
Incorporation of blood capillaries in engineered tissues and their functional connection to host blood vessels is essential for success in engineering vascularized tissues, a process which involves spatial patterning of...
3.
Naghipour S, Corben L, Hulme A, Dottori M, Delatycki M, Lees J, et al.
Mov Disord . 2024 Nov; 40(2):226-230. PMID: 39559924
No abstract available.
4.
Donner D, Kong A, Lees J, Kiriazis H, Brown A, Tham Y, et al.
Cardiovasc Drugs Ther . 2024 Oct; PMID: 39432235
No abstract available.
5.
Yin J, Lees J, Gong S, Nguyen J, Phang R, Shi Q, et al.
Biosens Bioelectron . 2024 Sep; 267:116752. PMID: 39276439
Cardiac organoids differentiated from induced pluripotent stem cells are emerging as a promising platform for pre-clinical drug screening, assessing cardiotoxicity, and disease modelling. However, it is challenging to simultaneously measure...
6.
Claridge B, Rai A, Lees J, Fang H, Lim S, Greening D
J Extracell Biol . 2024 Jun; 2(12):e125. PMID: 38938901
Pathological reprogramming of cardiomyocyte and fibroblast proteome landscapes drive the initiation and progression of cardiac fibrosis. Although the secretome of dysfunctional cardiomyocytes is emerging as an important driver of pathological...
7.
Wang J, Urrutia-Cabrera D, Lees J, Mesa Mora S, Nguyen T, Hung S, et al.
Int J Mol Sci . 2023 Feb; 24(4). PMID: 36834828
Age-related macular degeneration (AMD) is a blinding disease characterised by dysfunction of the retinal pigmented epithelium (RPE) which culminates in disruption or loss of the neurosensory retina. Genome-wide association studies...
8.
Nguyen T, Urrutia-Cabrera D, Wang L, Lees J, Wang J, Hung S, et al.
Aging (Albany NY) . 2023 Feb; 15(6):1713-1733. PMID: 36795578
Genetic and epidemiologic studies have significantly advanced our understanding of the genetic factors contributing to age-related macular degeneration (AMD). In particular, recent expression quantitative trait loci (eQTL) studies have highlighted...
9.
Daniszewski M, Senabouth A, Liang H, Han X, Lidgerwood G, Hernandez D, et al.
Cell Genom . 2023 Feb; 2(6):100142. PMID: 36778138
To assess the transcriptomic profile of disease-specific cell populations, fibroblasts from patients with primary open-angle glaucoma (POAG) were reprogrammed into induced pluripotent stem cells (iPSCs) before being differentiated into retinal...
10.
Kong A, Lim S, Palmer J, Rixon A, Gerrand Y, Yap K, et al.
J Tissue Eng . 2023 Jan; 13:20417314221140979. PMID: 36600999
Due to a relative paucity of studies on human lymphatic assembly in vitro and subsequent in vivo transplantation, capillary formation and survival of primary human lymphatic (hLEC) and blood endothelial...