Priyadharshini Sivakumaran
Overview
Explore the profile of Priyadharshini Sivakumaran including associated specialties, affiliations and a list of published articles.
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18
Citations
305
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Recent Articles
1.
Daniszewski M, Senabouth A, Liang H, Han X, Lidgerwood G, Hernandez D, et al.
Cell Genom
. 2023 Feb;
2(6):100142.
PMID: 36778138
To assess the transcriptomic profile of disease-specific cell populations, fibroblasts from patients with primary open-angle glaucoma (POAG) were reprogrammed into induced pluripotent stem cells (iPSCs) before being differentiated into retinal...
2.
Hernandez D, Millard R, Kong A, Burns O, Sivakumaran P, Shepherd R, et al.
Bioelectricity
. 2021 Sep;
2(4):391-398.
PMID: 34476368
Cardiomyocytes derived from pluripotent stem cells are immature. Maturation of cardiomyocytes is a multifactorial dynamic process that involves various factors that cannot be fully recapitulated . Here, we report a...
3.
Watson A, Gould E, Moody S, Sivakumaran P, Sourris K, Chow B, et al.
Front Physiol
. 2020 Jun;
11:518.
PMID: 32581831
It is well established that diabetes is the major cause of chronic kidney disease worldwide. Both hyperglycemia, and more recently, advanced glycation endproducts, have been shown to play critical roles...
4.
Kompa A, Greening D, Kong A, McMillan P, Fang H, Saxena R, et al.
Cardiovasc Res
. 2020 Apr;
117(3):918-929.
PMID: 32251516
Aims: To establish pre-clinical proof of concept that sustained subcutaneous delivery of the secretome of human cardiac stem cells (CSCs) can be achieved in vivo to produce significant cardioreparative outcomes...
5.
Lees J, Kong A, Chen Y, Sivakumaran P, Hernandez D, Pebay A, et al.
Stem Cells Int
. 2019 Oct;
2019:6380135.
PMID: 31641358
Human induced pluripotent stem cells (iPSCs) can be differentiated into cardiomyocytes for disease modelling and personalized medicine. Mitochondrial morphology and metabolism change dramatically as iPSCs differentiate into mesodermal cardiac lineages....
6.
Daniszewski M, Nguyen Q, Chy H, Singh V, Crombie D, Kulkarni T, et al.
iScience
. 2018 Sep;
7:30-39.
PMID: 30267684
We assessed the pluripotency of human induced pluripotent stem cells (iPSCs) maintained on an automated platform using StemFlex and TeSR-E8 media. Analysis of transcriptome of single cells revealed similar expression...
7.
Hoque A, Sivakumaran P, Bond S, Ling N, Kong A, Scott J, et al.
Cell Death Discov
. 2018 Mar;
4:39.
PMID: 29531836
Human induced pluripotent stem cells (iPSCs) are a valuable tool for studying the cardiac developmental process in vitro, and cardiomyocytes derived from iPSCs are a putative cell source for personalized...
8.
Nie S, Wang X, Sivakumaran P, Chong M, Liu X, Karnezis T, et al.
Sci Rep
. 2018 Jan;
8(1):1579.
PMID: 29371689
The benefits of adult stem cells for repair of the heart have been attributed to the repertoire of salutary paracrine activities they appear to exert. We previously isolated human W8B2...
9.
Rosdah A, Bond S, Sivakumaran P, Hoque A, Oakhill J, Drew B, et al.
Stem Cells Dev
. 2017 Oct;
26(24):1771-1780.
PMID: 29054138
Cardiac stem cell (CSC) therapy is a promising approach to treat ischemic heart disease. However, the poor survival of transplanted stem cells in the ischemic myocardium has been a major...
10.
Crombie D, Curl C, Raaijmakers A, Sivakumaran P, Kulkarni T, Wong R, et al.
Aging (Albany NY)
. 2017 Jun;
9(5):1440-1452.
PMID: 28562313
We sought to identify the impacts of Friedreich's ataxia (FRDA) on cardiomyocytes. FRDA is an autosomal recessive degenerative condition with neuronal and non-neuronal manifestations, the latter including progressive cardiomyopathy of...