Shengkan Jin
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Explore the profile of Shengkan Jin including associated specialties, affiliations and a list of published articles.
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42
Citations
11941
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Recent Articles
1.
Porreca I, Blassberg R, Harbottle J, Joubert B, Mielczarek O, Stombaugh J, et al.
Mol Ther
. 2024 Jun;
32(8):2692-2710.
PMID: 38937969
Gene editing technologies hold promise for enabling the next generation of adoptive cellular therapies. In conventional gene editing platforms that rely on nuclease activity, such as clustered regularly interspaced short...
2.
da Silva-Diz V, Cao B, Lancho O, Chiles E, Alasadi A, Aleksandrova M, et al.
Blood
. 2021 Apr;
138(15):1317-1330.
PMID: 33876224
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy. Despite recent advances in treatments with intensified chemotherapy regimens, relapse rates and associated morbidities remain high. In this context, metabolic...
3.
Alasadi A, Cao B, Guo J, Tao H, Collantes J, Tan V, et al.
Oncogene
. 2021 Mar;
40(12):2285-2295.
PMID: 33649533
Pancreatic ductal adenocarcinoma (PDA) is aggressive cancer characterized by rapid progression, metastatic recurrence, and highly resistant to treatment. PDA cells exhibit aerobic glycolysis, or the Warburg effect, which reduces the...
4.
Collantes J, Tan V, Xu H, Ruiz-Uriguen M, Alasadi A, Guo J, et al.
CRISPR J
. 2021 Feb;
4(1):58-68.
PMID: 33616445
Conventional CRISPR approaches for precision genome editing rely on the introduction of DNA double-strand breaks (DSB) and activation of homology-directed repair (HDR), which is inherently genotoxic and inefficient in somatic...
5.
Alasadi A, Chen M, Swapna G, Tao H, Guo J, Collantes J, et al.
Cell Death Dis
. 2018 Feb;
9(2):215.
PMID: 29440715
Metabolism of cancer cells is characterized by aerobic glycolysis, or the Warburg effect. Aerobic glycolysis reduces pyruvate flux into mitochondria, preventing a complete oxidation of glucose and shunting glucose to...
6.
Guo J, Tao H, Alasadi A, Huang Q, Jin S
Eat Weight Disord
. 2017 Aug;
24(1):91-96.
PMID: 28780747
Purpose: Obesity and type 2 diabetes (T2D) have become the major public health challenges globally. Mitochondrial uncoupling, which reduces intracellular lipid loads and corrects the underlying cause of insulin resistance,...
7.
Williams J, Zhao K, Jin S, Ding W
Exp Biol Med (Maywood)
. 2017 Jan;
242(8):781-787.
PMID: 28093935
Removal of damaged mitochondria through mitophagy is critical for maintaining cellular homeostasis and functions. Increasing evidence implicates mitophagy in red blood cell differentiation, neurodegeneration, macrophage-mediated inflammation, ischemia, adipogenesis, drug-induced tissue...
8.
Ding R, Jin S, Pabon K, Scotto K
Autophagy
. 2016 Mar;
12(5):737-51.
PMID: 26983466
The ABC drug transporters, including ABCG2, are well known for their ability to efflux a wide spectrum of chemotherapeutic agents, thereby conferring a multidrug-resistant phenotype. However, studies over the past...
9.
Klionsky D, Abdelmohsen K, Abe A, Abedin M, Abeliovich H, Arozena A, et al.
Autophagy
. 2016 Jan;
12(1):1-222.
PMID: 26799652
No abstract available.
10.
Tao H, Zhang Y, Zeng X, Shulman G, Jin S
Nat Med
. 2014 Oct;
20(11):1263-9.
PMID: 25282357
Type 2 diabetes (T2D) has reached an epidemic level globally. Most current treatments ameliorate the hyperglycemic symptom of the disease but are not effective in correcting its underlying cause. One...