Shen-Xi Ouyang
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Explore the profile of Shen-Xi Ouyang including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
67
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Recent Articles
1.
Ouyang S, Xu Y, Ding P, Long Y, Zhang Z, Sun S, et al.
Toxicology
. 2025 Jan;
511:154058.
PMID: 39828240
Acetaminophen (APAP) stands as one of the most prevalent triggers of drug-induced acute liver injury (ALI). The intricate modulation of immune system activation and inflammatory cascades by hepatic immune cells...
2.
Sun D, Wu W, Wu J, Shi Y, Xu J, Ouyang S, et al.
Nat Commun
. 2024 Nov;
15(1):9874.
PMID: 39543124
No abstract available.
3.
Sun S, Jiao X, Chen Z, Cao Q, Zhu J, Shen Q, et al.
Nat Commun
. 2024 Aug;
15(1):6640.
PMID: 39103324
Immune checkpoint inhibitor (ICI)-induced myocarditis involves intensive immune/inflammation activation; however, its molecular basis is unclear. Here, we show that gasdermin-E (GSDME), a gasdermin family member, drives ICI-induced myocarditis. Pyroptosis mediated...
4.
Zhu J, Ouyang S, Zhang G, Cao Q, Xin R, Yin H, et al.
Cell Death Differ
. 2024 Jul;
31(11):1467-1486.
PMID: 39009654
Dysregulated metabolism, cell death, and inflammation contribute to the development of metabolic dysfunction-associated steatohepatitis (MASH). Pyroptosis, a recently identified form of programmed cell death, is closely linked to inflammation. However,...
5.
Ouyang S, Zhu J, Cao Q, Liu J, Zhang Z, Zhang Y, et al.
Adv Sci (Weinh)
. 2024 Feb;
11(16):e2305715.
PMID: 38417117
Drug-induced liver injury (DILI) is a significant global health issue that poses high mortality and morbidity risks. One commonly observed cause of DILI is acetaminophen (APAP) overdose. GSDME is an...
6.
Sun D, Wu W, Wu J, Shi Y, Xu J, Ouyang S, et al.
Nat Commun
. 2024 Feb;
15(1):1429.
PMID: 38365899
Senescence of vascular smooth muscle cells (VSMCs) contributes to aging-related cardiovascular diseases by promoting arterial remodelling and stiffness. Ferroptosis is a novel type of regulated cell death associated with lipid...
7.
Li Z, Xu F, Fu J, Ouyang S, Cao Q, Yan Y, et al.
Int Immunopharmacol
. 2023 Dec;
125(Pt A):111133.
PMID: 38149573
Acetaminophen (N-acetyl-p-aminophenol; APAP), a widely used effective nonsteroidal anti-inflammatory drug, leads to acute liver injury at overdose worldwide. Evidence showed that the severity of liver injury associated with the subsequent...
8.
Li D, Sun S, Fu J, Ouyang S, Zhao Q, Su L, et al.
Theranostics
. 2021 Mar;
11(9):4381-4402.
PMID: 33754067
Nicotinamide adenine dinucleotide (NAD)-boosting therapy has emerged as a promising strategy to treat various health disorders, while the underlying molecular mechanisms are not fully understood. Here, we investigated the involvement...
9.
Hua X, Sun D, Zhang W, Fu J, Tong J, Sun S, et al.
Br J Pharmacol
. 2020 Feb;
178(10):2111-2130.
PMID: 32037512
Background And Purpose: Non-alcoholic fatty liver disease (NAFLD) is a worldwide public health problem with no established pharmacological therapy. Here, we explored the potential benefit of P7C3-A20, a novel aminopropyl...