Shelby L Steele
Overview
Explore the profile of Shelby L Steele including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
280
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0
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Recent Articles
1.
Giamberardino C, Tenor J, Toffaletti D, Palmucci J, Schell W, Boua J, et al.
Antimicrob Agents Chemother
. 2023 Sep;
67(10):e0081823.
PMID: 37728934
Cryptococcal meningoencephalitis (CM) is a devastating fungal disease with high morbidity and mortality. The current regimen that is standard-of-care involves a combination of three different drugs administered for up to...
2.
MacLean J, Wertman J, Prykhozhij S, Chedrawe E, Langley S, Steele S, et al.
Genes (Basel)
. 2023 May;
14(5).
PMID: 37239446
CHARGE syndrome typically results from mutations in the gene encoding chromodomain helicase DNA-binding protein 7 (). CHD7 is involved in regulating neural crest development, which gives rise to tissues of...
3.
Wertman J, Melong N, Stoyek M, Piccolo O, Langley S, Orr B, et al.
Elife
. 2020 Jul;
9.
PMID: 32720645
Dose-limiting toxicities for cisplatin administration, including ototoxicity and nephrotoxicity, impact the clinical utility of this effective chemotherapy agent and lead to lifelong complications, particularly in pediatric cancer survivors. Using a...
4.
Prykhozhij S, Fuller C, Steele S, Veinotte C, Razaghi B, Robitaille J, et al.
Nucleic Acids Res
. 2018 Jul;
46(17):9252.
PMID: 30053067
No abstract available.
5.
Prykhozhij S, Fuller C, Steele S, Veinotte C, Razaghi B, Robitaille J, et al.
Nucleic Acids Res
. 2018 Jun;
46(17):e102.
PMID: 29905858
We have optimized point mutation knock-ins into zebrafish genomic sites using clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 reagents and single-stranded oligodeoxynucleotides. The efficiency of knock-ins was assessed by a novel...
6.
Cloney K, Steele S, Stoyek M, Croll R, Smith F, Prykhozhij S, et al.
FEBS J
. 2018 Apr;
285(11):2125-2140.
PMID: 29660852
CHARGE syndrome is linked to autosomal-dominant mutations in the CHD7 gene and results in a number of physiological and structural abnormalities, including heart defects, hearing and vision loss, and gastrointestinal...
7.
Razaghi B, Steele S, Prykhozhij S, Stoyek M, Hill J, Cooper M, et al.
Dev Dyn
. 2017 Oct;
247(2):289-303.
PMID: 29024245
Background: In this study, we reveal a previously undescribed role of the HACE1 (HECT domain and Ankyrin repeat Containing E3 ubiquitin-protein ligase 1) tumor suppressor protein in normal vertebrate heart...
8.
Prykhozhij S, Steele S, Razaghi B, Berman J
Dis Model Mech
. 2017 Mar;
10(6):811-822.
PMID: 28280001
Clustered regularly interspaced palindromic repeats (CRISPR)/Cas-based adaptive immunity against pathogens in bacteria has been adapted for genome editing and applied in zebrafish () to generate frameshift mutations in protein-coding genes....
9.
Fernandez-Murray J, Prykhozhij S, Dufay J, Steele S, Gaston D, Nasrallah G, et al.
PLoS Genet
. 2016 Jan;
12(1):e1005783.
PMID: 26821380
Sideroblastic anemias are acquired or inherited anemias that result in a decreased ability to synthesize hemoglobin in red blood cells and result in the presence of iron deposits in the...
10.
Steele S, Prykhozhij S, Berman J
Transl Res
. 2013 Sep;
163(2):79-98.
PMID: 24055494
Animal models for studying human disease are essential to the continuing evolution of medicine. Rodent models are attractive for the obvious similarities in development and genetic makeup compared with humans,...