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Sheena Sharma

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Articles 34
Citations 277
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Recent Articles
1.
Weber M, Hehn F, Huynh Y, Remkes A, Strunz-Lehner C, Hauser I, et al.
Pediatr Allergy Immunol . 2024 Oct; 35(10):e14251. PMID: 39365274
Background: Consumption of raw cow's milk has repeatedly been shown to protect from asthma, allergies, and respiratory infections. As raw milk bears potential health hazards, it cannot be recommended for...
2.
Soltantabar P, Sharma S, Wang D, Lon H, Czibere A, Hickmann A, et al.
Clin Pharmacol Ther . 2024 Mar; 115(6):1258-1268. PMID: 38459622
B-cell maturation antigen (BCMA)-targeting immunotherapies (e.g., chimeric antigen receptor T cells (CAR-T) and bispecific antibodies (BsAbs)) have achieved remarkable clinical responses in patients with relapsed and/or refractory multiple myeloma (RRMM)....
3.
Sharma S, Kogan C, Varma M, Prasad B
Drug Metab Pharmacokinet . 2023 Oct; 53:100518. PMID: 37856928
The effect of food on oral drug absorption is determined by the complex interplay among gut physiological factors and drug properties. The currently used dissolution testing and classification systems (biopharmaceutics...
4.
Sharma S, Mettu V, Prasad B
Pharmaceutics . 2023 Feb; 15(2). PMID: 36839862
Poor and variable oral bioavailability of furosemide (FUR) presents critical challenges in pharmacotherapy. We investigated the interplay of breast cancer resistance protein (Bcrp)-mediated transport, sex, and fed state on FUR...
5.
Sharma S, Singh D, Mettu V, Yue G, Ahire D, Basit A, et al.
Mol Pharm . 2023 Feb; 20(3):1737-1749. PMID: 36791335
Rats are extensively used as a preclinical model for assessing drug pharmacokinetics (PK) and tissue distribution; however, successful translation of the rat data requires information on the differences in drug...
6.
Sharma S, Ahire D, Basit A, Lajoie M, Wang C, Lee M, et al.
Drug Metab Dispos . 2022 Oct; 50(12):1493-1500. PMID: 36184078
Dimethandrolone undecanoate (DMAU), an oral investigational male hormonal contraceptive, is a prodrug that is rapidly converted to its active metabolite, dimethandrolone (DMA). Poor and variable oral bioavailability of DMA after...
7.
Ahire D, Kruger L, Sharma S, Mettu V, Basit A, Prasad B
Pharmacol Rev . 2022 Jun; 74(3):769-796. PMID: 35738681
A reliable translation of in vitro and preclinical data on drug absorption, distribution, metabolism, and excretion (ADME) to humans is important for safe and effective drug development. Precision medicine that...
8.
Ladumor M, Paudel A, Modhave D, Sharma S, Balhara A, Singh D, et al.
J Pharm Sci . 2021 Oct; 111(5):1224-1231. PMID: 34699842
This commentary presents contributions and accomplishments of Professor Saranjit Singh, National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar, India, to pharmaceutical research and education. Prof. Singh completed his...
9.
Sharma S, Prasad B
Pharmaceutics . 2021 Aug; 13(7). PMID: 34371727
The oral route of drug administration is the most convenient method of drug delivery, but it is associated with variable bioavailability. Food is one of the major factors that affect...
10.
Muff-Luett M, Sanderson K, Engen R, Zahr R, Wenderfer S, Tran C, et al.
Pediatr Nephrol . 2021 Mar; 36(8):2349-2360. PMID: 33693990
Background: Eculizumab is approved for the treatment of atypical hemolytic uremic syndrome (aHUS). Its use off-label is frequently reported. The aim of this study was to describe the broader use...