Sheelagh Duncan
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Explore the profile of Sheelagh Duncan including associated specialties, affiliations and a list of published articles.
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11
Citations
424
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Recent Articles
1.
Cheng K, Fingerhut L, Duncan S, Prajna N, Rossi A, Mills B
Prog Retin Eye Res
. 2024 Jul;
102:101287.
PMID: 39004166
Microbial keratitis (MK) is an infection of the cornea, caused by bacteria, fungi, parasites, or viruses. MK leads to significant morbidity, being the fifth leading cause of blindness worldwide. There...
2.
Lochenie C, Duncan S, Zhou Y, Fingerhut L, Kiang A, Benson S, et al.
Adv Mater
. 2024 May;
36(31):e2404107.
PMID: 38762778
The emergence of multidrug resistant (MDR) pathogens and the scarcity of new potent antibiotics and antifungals are one of the biggest threats to human health. Antimicrobial photodynamic therapy (aPDT) combines...
3.
Gunasekaran R, Chandrasekaran A, Rajarathinam K, Duncan S, Dhaliwal K, Lalitha P, et al.
JAMA Ophthalmol
. 2023 Sep;
141(10):966-973.
PMID: 37768674
Importance: Microbial keratitis (MK) is a common cause of unilateral visual impairment, blindness, and eye loss in low-income and middle-income countries. There is an urgent need to develop and implement...
4.
Mohanan S, Russell K, Duncan S, Kiang A, Lochenie C, Duffy E, et al.
Transl Vis Sci Technol
. 2023 Jul;
12(7):1.
PMID: 37395707
Purpose: Rapid and accurate diagnosis of microbial keratitis (MK) could greatly improve patient outcomes. Here, we present the development of a rapid, accessible multicolour fluorescence imaging device (FluoroPi) and evaluate...
5.
Mills B, Megia-Fernandez A, Norberg D, Duncan S, Marshall A, Akram A, et al.
Eur J Nucl Med Mol Imaging
. 2020 Sep;
48(3):800-807.
PMID: 32915268
Purpose: The relentless rise in antimicrobial resistance is a major societal challenge and requires, as part of its solution, a better understanding of bacterial colonization and infection. To facilitate this,...
6.
Ucuncu M, Mills B, Duncan S, Staderini M, Dhaliwal K, Bradley M
Chem Commun (Camb)
. 2020 Mar;
56(26):3757-3760.
PMID: 32125330
Here we report the synthesis of a novel methylene blue-polymyxin conjugate and demonstrate its light-mediated killing of Gram-negative bacteria on skin models of infection demonstrating a 10 decrease in bacterial...
7.
Sutherland T, Ruckerl D, Logan N, Duncan S, Wynn T, Allen J
PLoS Pathog
. 2018 Dec;
14(11):e1007423.
PMID: 30500858
Ym1 and RELMα are established effector molecules closely synonymous with Th2-type inflammation and associated pathology. Here, we show that whilst largely dependent on IL-4Rα signaling during a type 2 response,...
8.
Ruckerl D, Campbell S, Duncan S, Sutherland T, Jenkins S, Hewitson J, et al.
PLoS Pathog
. 2017 Mar;
13(3):e1006233.
PMID: 28334040
Rapid reprogramming of the macrophage activation phenotype is considered important in the defense against consecutive infection with diverse infectious agents. However, in the setting of persistent, chronic infection the functional...
9.
Jackson-Jones L, Ruckerl D, Svedberg F, Duncan S, Maizels R, Sutherland T, et al.
Eur J Immunol
. 2016 Sep;
46(10):2311-2321.
PMID: 27592711
IL-33 plays an important role in the initiation of type-2 immune responses, as well as the enhancement of type 2 effector functions. Engagement of the IL-33 receptor on macrophages facilitates...
10.
Jenkins S, Ruckerl D, Thomas G, Hewitson J, Duncan S, Brombacher F, et al.
J Exp Med
. 2013 Oct;
210(11):2477-91.
PMID: 24101381
Macrophages (MΦs) colonize tissues during inflammation in two distinct ways: recruitment of monocyte precursors and proliferation of resident cells. We recently revealed a major role for IL-4 in the proliferative...