Shaun Willimott
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Explore the profile of Shaun Willimott including associated specialties, affiliations and a list of published articles.
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14
Citations
256
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Recent Articles
1.
Smallwood D, Apollonio B, Willimott S, Lezina L, Alharthi A, Ambrose A, et al.
Blood
. 2016 Apr;
128(4):542-52.
PMID: 27118451
The complex interplay between cancer cells, stromal cells, and immune cells in the tumor microenvironment (TME) regulates tumorigenesis and provides emerging targets for immunotherapies. Crosstalk between CD4(+) T cells and...
2.
AHearne M, Willimott S, Pinon L, Kennedy D, Miall F, Dyer M, et al.
Br J Haematol
. 2013 May;
162(3):360-70.
PMID: 23710828
Chronic lymphocytic leukaemia (CLL) cells encounter T-cells and proliferate in response to T-cell signals in the lymph node microenvironment. In this report we determined interleukin 21 (IL21) function in CLL...
3.
Willimott S, Beck D, AHearne M, Adams V, Wagner S
Clin Cancer Res
. 2013 May;
19(12):3212-23.
PMID: 23633452
Purpose: The lymph node microenvironment promotes resistance to chemotherapy in chronic lymphocytic leukemia (CLL), partly through induction of BCL2 family prosurvival proteins. Currently available inhibitors do not target all BCL2...
4.
Willimott S, Wagner S
J Biol Chem
. 2011 Dec;
287(4):2608-17.
PMID: 22139839
Developmental stage-specific regulation of BCL2 occurs during B-cell maturation and has a role in normal immunity. CD40 signaling promotes proliferation and rescues B-cells from apoptosis, partly through induction of BCL2L1...
5.
Willimott S, Merriam T, Wagner S
Biochem Biophys Res Commun
. 2011 Jan;
405(3):480-5.
PMID: 21256112
The Bcl-X gene has both pro-survival, Bcl-XL, and pro-apoptotic, Bcl-XS, gene products, which are produced by alternative splicing. The function of these proteins has previously been characterised in cell lines,...
6.
Willimott S, Wagner S
Biochem Soc Trans
. 2010 Dec;
38(6):1571-5.
PMID: 21118128
Bcl2 is an important pro-survival protein that has an essential function in normal immunity and whose constitutive expression leads to the development of lymphomas. Although transcriptional control of Bcl2 has...
7.
Willimott S, Barker J, Jones L, Opara E
Chem Cent J
. 2009 Sep;
3:12.
PMID: 19785738
Background: Long Dan Xie Gan Wan (LD), a Chinese herbal remedy formulation, is traditionally used to treat a range of conditions, including gall bladder diseases, hepatitis, hyperthyroidism, migraines but it...
8.
Khorashad J, Wagner S, Greener L, Marin D, Reid A, Milojkovic D, et al.
Haematologica
. 2009 Apr;
94(6):861-4.
PMID: 19377081
Imatinib is currently the first line therapy for newly diagnosed patients with chronic myeloid leukemia. However, 20-25% of patients do not achieve durable complete cytogenetic responses. The mechanism underlying this...
9.
Batlle A, Papadopoulou V, Gomes A, Willimott S, Melo J, Naresh K, et al.
Mol Immunol
. 2009 Mar;
46(8-9):1727-35.
PMID: 19268365
Bcl-6 is essential for germinal centre development and normal antibody responses, and has major roles in controlling B-cell proliferation and differentiation. Bcl-6 expression is tightly controlled, but neither the nature...
10.
Ambrose H, Willimott S, Beswick R, Dantzer F, Menissier de Murcia J, Yelamos J, et al.
Immunology
. 2008 Sep;
127(2):178-86.
PMID: 18778284
Poly(ADP-ribosylation) of acceptor proteins is an epigenetic modification involved in DNA strand break repair, recombination and transcription. Here we provide evidence for the involvement of poly(ADP-ribose) polymerase-1 (Parp-1) in antibody...