Shashi Shekhar Singh
Overview
Explore the profile of Shashi Shekhar Singh including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
241
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Recent Articles
1.
Mishra S, Welch N, Singh S, Singh K, Bellar A, Kumar A, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(31):e2314760121.
PMID: 39052834
Transceptors, solute transporters that facilitate intracellular entry of molecules and also initiate intracellular signaling events, have been primarily studied in lower-order species. Ammonia, a cytotoxic endogenous metabolite, is converted to...
2.
Mishra S, Welch N, Karthikeyan M, Bellar A, Musich R, Singh S, et al.
Aging Cell
. 2023 Apr;
22(7):e13852.
PMID: 37101412
Perturbed metabolism of ammonia, an endogenous cytotoxin, causes mitochondrial dysfunction, reduced NAD /NADH (redox) ratio, and postmitotic senescence. Sirtuins are NAD -dependent deacetylases that delay senescence. In multiomics analyses, NAD...
3.
Attaway A, Bellar A, Mishra S, Karthikeyan M, Sekar J, Welch N, et al.
J Physiol
. 2022 Dec;
601(3):567-606.
PMID: 36533558
Nocturnal hypoxaemia, which is common in chronic obstructive pulmonary disease (COPD) patients, is associated with skeletal muscle loss or sarcopenia, which contributes to adverse clinical outcomes. In COPD, we have...
4.
Welch N, Singh S, Musich R, Mansuri M, Bellar A, Mishra S, et al.
iScience
. 2022 Nov;
25(11):105325.
PMID: 36345342
Skeletal muscle generation of ammonia, an endogenous cytotoxin, is increased during exercise. Perturbations in ammonia metabolism consistently occur in chronic diseases, and may blunt beneficial skeletal muscle molecular responses and...
5.
Singh S, Mansuri M, Naiyer S, Kaur D, Agrahari M, Srinivasan S, et al.
Proteomics
. 2022 Sep;
22(22):e2200148.
PMID: 36066285
Entamoeba histolytica is responsible for dysentery and extraintestinal disease in humans. To establish successful infection, it must generate adaptive response against stress due to host defense mechanisms. We have developed...
6.
Naiyer S, Singh S, Kaur D, Mukherjee A, Singh Y, Bhattacharya A, et al.
Exp Parasitol
. 2022 Jun;
239:108308.
PMID: 35718007
Ribosome biogenesis, a multi-step process involving transcription, modification, folding and processing of rRNA, is the major consumer of cellular energy. It involves sequential assembly of ribosomal proteins (RP)s via more...
7.
Kumar A, Welch N, Mishra S, Bellar A, Silva R, Li L, et al.
JCI Insight
. 2021 Dec;
6(24).
PMID: 34935641
Ammonia is a cytotoxic metabolite with pleiotropic molecular and metabolic effects, including senescence induction. During dysregulated ammonia metabolism, which occurs in chronic diseases, skeletal muscle becomes a major organ for...
8.
Das S, Shukla N, Singh S, Kushwaha S, Shrivastava R
Apoptosis
. 2021 Sep;
26(9-10):512-533.
PMID: 34510317
The mechanisms of two programmed cell death pathways, autophagy, and apoptosis, are extensively focused areas of research in the context of cancer. Both the catabolic pathways play a significant role...
9.
Welch N, Singh S, Kumar A, Dhruba S, Mishra S, Sekar J, et al.
J Biol Chem
. 2021 Aug;
297(3):101023.
PMID: 34343564
Ammonia is a cytotoxic molecule generated during normal cellular functions. Dysregulated ammonia metabolism, which is evident in many chronic diseases such as liver cirrhosis, heart failure, and chronic obstructive pulmonary...
10.
Singh S, Kumar A, Welch N, Sekar J, Mishra S, Bellar A, et al.
Cell Physiol Biochem
. 2021 Feb;
55(1):91-116.
PMID: 33543862
Background/aims: Signaling and metabolic perturbations contribute to dysregulated skeletal muscle protein homeostasis and secondary sarcopenia in response to a number of cellular stressors including ethanol exposure. Using an innovative multiomics-based...