Sharon R Neufeldt
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Explore the profile of Sharon R Neufeldt including associated specialties, affiliations and a list of published articles.
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29
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468
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Recent Articles
1.
Jackson O, Reyes A, Stein C, Larson N, Andrews C, Neufeldt S
J Am Chem Soc
. 2025 Jan;
147(4):3017-3022.
PMID: 39829005
Under most conditions, 2,4-dihalopyrimidines undergo substitution reactions at C4. Here we report that Pd(II) precatalysts supported by bulky -heterocyclic carbene ligands uniquely effect C2-selective cross-coupling of 2,4-dichloropyrimidine with thiols. The...
2.
Kania M, Reyes A, Neufeldt S
J Am Chem Soc
. 2024 Jul;
146(28):19249-19260.
PMID: 38959060
Two limiting mechanisms are possible for oxidative addition of (hetero)aryl (pseudo)halides at Pd(0): a 3-centered concerted and a nucleophilic displacement mechanism. Until now, there has been little understanding about when...
3.
Larson N, Norman J, Neufeldt S
ACS Catal
. 2024 Jun;
14(9):7127-7135.
PMID: 38911468
We describe a detailed investigation into why bulky ligands-those that enable catalysis at "12 " Pd-tend to promote overfunctionalization during Pd-catalyzed cross-couplings of dihalogenated substrates. After one cross-coupling event takes...
4.
Duran-Camacho G, Bland D, Li F, Neufeldt S, Sanford M
ACS Catal
. 2024 Jun;
14(9):6404-6412.
PMID: 38911467
This report describes a detailed study of Ni phosphine catalysts for the Suzuki-Miyaura coupling of dichloropyridines with halogen-containing (hetero)aryl boronic acids. With most phosphine ligands these transformations afford mixtures of...
5.
Norman J, Larson N, Neufeldt S
ACS Catal
. 2023 Aug;
12(15):8822-8828.
PMID: 37601556
In cross-coupling reactions, dihaloheteroarenes are usually most reactive at C─halide bonds adjacent to a heteroatom. This selectivity has been previously rationalized. However, no mechanistic explanation exists for anomalous reports in...
6.
Sloane S, Vang Z, Nelson G, Qi L, Sonstrom R, Alansari I, et al.
JACS Au
. 2023 Jun;
3(6):1583-1589.
PMID: 37388686
A highly regio- and chemoselective Cu-catalyzed aryl alkyne transfer hydrodeuteration to access a diverse scope of aryl alkanes precisely deuterated at the benzylic position is described. The reaction benefits from...
7.
Ibsen G, Menezes da Silva V, Pettigrew J, Neufeldt S
Chem Asian J
. 2023 Mar;
18(9):e202300036.
PMID: 36965027
In the absence of strong ancillary ligands such as phosphines or N-heterocyclic carbenes, palladium salts are selective for C-OTf cleavage in the room-temperature Suzuki couplings of chloroaryl triflates in acetonitrile....
8.
Norman J, Neufeldt S
ACS Catal
. 2023 Feb;
12(19):12014-12026.
PMID: 36741273
The vast majority (≥90%) of literature reports agree on the regiochemical outcomes of Pd-catalyzed cross-coupling reactions for most classes of dihalogenated -heteroarenes. Despite a well-established mechanistic rationale for typical selectivity,...
9.
Ibsen G, Reeves E, Humke J, Neufeldt S
J Org Chem
. 2022 Oct;
87(21):14991-14992.
PMID: 36219844
No abstract available.
10.
Norman J, Larson N, Entz E, Neufeldt S
J Org Chem
. 2022 May;
87(11):7414-7421.
PMID: 35584051
Halides adjacent to nitrogen are conventionally more reactive in Pd-catalyzed cross-couplings of dihalogenated -heteroarenes. However, a very sterically hindered -heterocyclic carbene ligand is shown to promote room-temperature cross-coupling at C4...