Nathaniel G Larson
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Explore the profile of Nathaniel G Larson including associated specialties, affiliations and a list of published articles.
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3
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14
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Recent Articles
1.
Jackson O, Reyes A, Stein C, Larson N, Andrews C, Neufeldt S
J Am Chem Soc
. 2025 Jan;
147(4):3017-3022.
PMID: 39829005
Under most conditions, 2,4-dihalopyrimidines undergo substitution reactions at C4. Here we report that Pd(II) precatalysts supported by bulky -heterocyclic carbene ligands uniquely effect C2-selective cross-coupling of 2,4-dichloropyrimidine with thiols. The...
2.
Larson N, Norman J, Neufeldt S
ACS Catal
. 2024 Jun;
14(9):7127-7135.
PMID: 38911468
We describe a detailed investigation into why bulky ligands-those that enable catalysis at "12 " Pd-tend to promote overfunctionalization during Pd-catalyzed cross-couplings of dihalogenated substrates. After one cross-coupling event takes...
3.
Norman J, Larson N, Neufeldt S
ACS Catal
. 2023 Aug;
12(15):8822-8828.
PMID: 37601556
In cross-coupling reactions, dihaloheteroarenes are usually most reactive at C─halide bonds adjacent to a heteroatom. This selectivity has been previously rationalized. However, no mechanistic explanation exists for anomalous reports in...
4.
Norman J, Larson N, Entz E, Neufeldt S
J Org Chem
. 2022 May;
87(11):7414-7421.
PMID: 35584051
Halides adjacent to nitrogen are conventionally more reactive in Pd-catalyzed cross-couplings of dihalogenated -heteroarenes. However, a very sterically hindered -heterocyclic carbene ligand is shown to promote room-temperature cross-coupling at C4...