Sharadha Sakthikumar
Overview
Explore the profile of Sharadha Sakthikumar including associated specialties, affiliations and a list of published articles.
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25
Citations
6960
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Recent Articles
1.
Sakthikumar S, Warrier M, Whitley D, Facista S, Adkins J, Aman S, et al.
Vet Comp Oncol
. 2023 Dec;
22(1):30-41.
PMID: 38053317
A genomic understanding of the oncogenic processes and individual variability of human cancer has steadily fueled improvement in patient outcomes over the past 20 years. Mutations within tumour tissues are...
2.
Chon E, Sakthikumar S, Tang M, Hamilton M, Vaughan A, Smith A, et al.
J Vet Intern Med
. 2023 Oct;
37(6):2410-2421.
PMID: 37801037
Background: Growing evidence from dogs and humans supports the abundance of mutation-based biomarkers in tumors of dogs. Increasing the use of clinical genomic diagnostic testing now provides another powerful data...
3.
Roy A, Sakthikumar S, Kozyrev S, Nordin J, Pensch R, Makelainen S, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(33):e2300984120.
PMID: 37549291
Current knowledge of cancer genomics remains biased against noncoding mutations. To systematically search for regulatory noncoding mutations, we assessed mutations in conserved positions in the genome under the assumption that...
4.
Sakthikumar S, Facista S, Whitley D, Byron S, Ahmed Z, Warrier M, et al.
Vet Comp Oncol
. 2023 May;
21(3):482-491.
PMID: 37248814
The accrual of cancer mutation data and related functional and clinical associations have revolutionised human oncology, enabling the advancement of precision medicine and biomarker-guided clinical management. The catalogue of cancer...
5.
Sullivan P, Meadows J, Gazal S, Phan B, Li X, Genereux D, et al.
Science
. 2023 Apr;
380(6643):eabn2937.
PMID: 37104612
Thousands of genomic regions have been associated with heritable human diseases, but attempts to elucidate biological mechanisms are impeded by an inability to discern which genomic positions are functionally important....
6.
Sullivan P, Meadows J, Gazal S, Phan B, Li X, Genereux D, et al.
bioRxiv
. 2023 Mar;
PMID: 36945512
Although thousands of genomic regions have been associated with heritable human diseases, attempts to elucidate biological mechanisms are impeded by a general inability to discern which genomic positions are functionally...
7.
Chon E, Wang G, Whitley D, Sakthikumar S, Warrier M, Wong S, et al.
J Am Vet Med Assoc
. 2023 Mar;
261(5):668-677.
PMID: 36862546
Objective: To evaluate the diagnostic, prognostic, and therapeutic utility of a cancer genomic diagnostic assay (SearchLight DNA; Vidium Animal Health) for diagnostically ambiguous cancer cases. Animals: 69 privately owned dogs...
8.
Arendt M, Sakthikumar S, Melin M, Elvers I, Rivera P, Larsen M, et al.
Sci Rep
. 2023 Jan;
13(1):632.
PMID: 36635367
Biological features of neoplastic disease affecting mammary gland tissue are shared between canines and humans. Research performed in either species has translational value and early phase clinical trials performed in...
9.
Fellers J, Sakthikumar S, He F, McRell K, Bakkeren G, Cuomo C, et al.
G3 (Bethesda)
. 2021 Sep;
11(9).
PMID: 34544127
The wheat leaf rust fungus, Puccinia triticina Erikss., is a worldwide pathogen of tetraploid durum and hexaploid wheat. Many races of P. triticina differ for virulence to specific leaf rust...
10.
Sakthikumar S, Roy A, Haseeb L, Pettersson M, Sundstrom E, Marinescu V, et al.
Genome Biol
. 2020 Jun;
21(1):127.
PMID: 32513296
Background: Glioblastoma (GBM) has one of the worst 5-year survival rates of all cancers. While genomic studies of the disease have been performed, alterations in the non-coding regulatory regions of...