Christopher A Desjardins
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Explore the profile of Christopher A Desjardins including associated specialties, affiliations and a list of published articles.
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47
Citations
3469
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Recent Articles
1.
Young M, Straub T, Worby C, Metsky H, Gnirke A, Bronson R, et al.
Nat Commun
. 2024 Nov;
15(1):9466.
PMID: 39487120
Low-abundance members of microbial communities are difficult to study in their native habitats, including Escherichia coli, a minor but common inhabitant of the gastrointestinal tract, and key opportunistic pathogen of...
2.
Young M, Straub T, Worby C, Metsky H, Gnirke A, Bronson R, et al.
bioRxiv
. 2024 Mar;
PMID: 38463963
Low-abundance members of microbial communities are difficult to study in their native habitats. This includes , a minor, but common inhabitant of the gastrointestinal tract and opportunistic pathogen, including of...
3.
Worby C, Schreiber 4th H, Straub T, van Dijk L, Bronson R, Olson B, et al.
Nat Microbiol
. 2022 May;
7(5):630-639.
PMID: 35505248
Recurrent urinary tract infections (rUTIs) are a major health burden worldwide, with history of infection being a significant risk factor. While the gut is a known reservoir for uropathogenic bacteria,...
4.
Straub T, Chou W, Manson A, Schreiber 4th H, Walker B, Desjardins C, et al.
BMC Microbiol
. 2021 Feb;
21(1):53.
PMID: 33596852
Background: Urinary tract infections (UTIs) affect 15 million women each year in the United States, with > 20% experiencing frequent recurrent UTIs. A recent placebo-controlled clinical trial found a 39%...
5.
McGovern B, Ford C, Henn M, Pardi D, Khanna S, Hohmann E, et al.
Clin Infect Dis
. 2020 Apr;
72(12):2132-2140.
PMID: 32255488
Background: Recurrent Clostridioides difficile infection (rCDI) is associated with loss of microbial diversity and microbe-derived secondary bile acids, which inhibit C. difficile germination and growth. SER-109, an investigational microbiome drug...
6.
Yu C, Chen Y, Desjardins C, Tenor J, Toffaletti D, Giamberardino C, et al.
Microb Genom
. 2019 Dec;
6(1).
PMID: 31860441
is an opportunistic fungal pathogen that at its peak epidemic levels caused an estimated million cases of cryptococcal meningitis per year worldwide. This species can grow in diverse environmental (trees,...
7.
Cohen K, Manson A, Desjardins C, Abeel T, Earl A
Genome Med
. 2019 Jul;
11(1):45.
PMID: 31345251
Tuberculosis (TB) is a global infectious threat that is intensified by an increasing incidence of highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium tuberculosis, the causative agent of TB,...
8.
Cohen K, Manson A, Abeel T, Desjardins C, Chapman S, Hoffner S, et al.
Thorax
. 2019 May;
74(9):882-889.
PMID: 31048508
Background: While the international spread of multidrug-resistant (MDR) strains is an acknowledged public health threat, a broad and more comprehensive examination of the global spread of MDR-tuberculosis (TB) using whole-genome...
9.
Reddy K, Dror T, Underwood R, Osman G, Elder C, Desjardins C, et al.
PLoS Pathog
. 2019 Jan;
15(1):e1007528.
PMID: 30640956
Immune genes are under intense, pathogen-induced pressure, which causes these genes to diversify over evolutionary time and become species-specific. Through a forward genetic screen we recently described a C. elegans-specific...
10.
Georgescu C, Manson A, Griggs A, Desjardins C, Pironti A, Wapinski I, et al.
Microb Genom
. 2018 Nov;
4(11).
PMID: 30418868
Accurate orthologue identification is a vital component of bacterial comparative genomic studies, but many popular sequence-similarity-based approaches do not scale well to the large numbers of genomes that are now...